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JNJ-632

    
≥98%

JNJ-632

源叶(MedMol)
S88430 一键复制产品信息
1572510-42-9
C18H19FN2O4S
378.40
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
S88430-5mg促销
≥98%

¥220.00 ¥198.00

10 - - - -
S88430-10mg促销
≥98%

¥399.00 ¥359.00

10 - - - -
S88430-25mg促销
≥98%

¥474.00 ¥426.00

8 - - - -
S88430-50mg促销
≥98%

¥854.00 ¥768.00

1 - - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述: JNJ-632 是一种有效的 hepatitis B virus (HBV) capsid assembly modulator (CAM) 装配调节剂,在HepG2.2.15细胞中的平均EC50值为121 nM
靶点: HBV capsid(in HepG2.2.15 cells):121 nM(EC50);HBV
体内研究: JNJ-632, a N-phenyl-3-sulfamoyl-benzamide derivative and HBV capsid assembly modulator, can inhibit HBV in vivo (HBV infected humanized mice) resulting in a 2.77 log reduction of HBV DNA viral load
细胞实验: Cell lines: HBV (genotype A- to D)-infected primary human hepatocytes derived from naive chimeric mice Concentrations: -- Incubation Time: 4 days Method: Cells were cultured in RPMI 1640 medium supplemented with 2% FBS and incubated for 4 days at 37 ℃ in a 5% CO2 atmosphere in the presence or absence of serially diluted (1:4) JNJ-632. The cytotoxicity of the JNJ-632 was measured using the resazurin readout, and EC50 and EC90 values were calculated.
动物实验: Animal Models: HBV Genotype D Infected Chimeric Mice Dosages: 200 mg/kg/day Administration: s.c.
参考文献: 1. Jan Martin Berke, et al. Antimicrob Agents Chemother. 2017 Jul 25;61(8):e00560-17. 2. Berke JM, et al. Antimicrob Agents Chemother. 2017;61(8):e00560-17. 3. Vandyck K, et al. J Med Chem. 2018 Jul 26;61(14):6247-6260.
溶解性: Soluble  in  DMSO、Ethanol
保存条件: -20°C
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.643 ml 13.214 ml 26.427 ml
5 mM 0.529 ml 2.643 ml 5.285 ml
10 mM 0.264 ml 1.321 ml 2.643 ml
50 mM 0.053 ml 0.264 ml 0.529 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

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摩尔浓度计算器

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