货号	规格	价格	上海	北京	珠海	重庆	武汉
S88446-1mg买3赠1	99.30%	￥260.00 S88446-1mg ￥260.00 现货（买3赠1）	4 4	-	-	-	-
S88446-5mg买3赠1	99.30%	￥450.00 S88446-5mg ￥450.00 现货（买3赠1）	3 3	-	-	-	-
S88446-10mg买3赠1	99.30%	￥690.00 S88446-10mg ￥690.00 现货（买3赠1）	4 4	-	-	-	-
S88446-25mg促销	99.30%	￥1520.00 ￥1210.00 S88446-25mg ￥1210.00 现货	5 5	-	-	-	-
S88446-50mg促销	≥98%	￥2110.00 ￥1680.00 S88446-50mg ￥1680.00 2-3天	0 货期：2-3天	-	-	-	-
S88446-100mg促销	≥98%	￥3920.00 ￥3130.00 S88446-100mg ￥3130.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

KY-226 是一种有效的、口服活性的 protein tyrosine phosphatase 1B (PTP1B) 的选择性变构抑制剂，对人PTP1B的IC50值为0.28 μM。KY-226 通过增强 insulin 和 leptin 信号传导来发挥抗糖尿病和抗肥胖的作用

靶点：

PTP1B(Cell-free assay):0.28 μM;Phosphatase

体内研究：

In db/db mice, the oral administration of KY-226 (10 and 30 mg/kg/day, 4 weeks) significantly reduces plasma glucose and triglyceride levels as well as hemoglobin A1c values without increasing body weight gain. KY-226 attenuates plasma glucose elevations in the oral glucose tolerance test. KY-226 also increases pIR and phosphorylated Akt in the liver and femoral muscle. In high-fat diet-induced obese mice, the oral administration of KY-226 (30 and 60 mg/kg/day, 4 weeks) decreases body weight gain, food consumption, and fat volume gain with increases in phosphorylated STAT3 in the hypothalamus.

细胞实验：

Cell lines: 3T3-L1, HepG2 Concentrations: 0.1-10 μM Incubation Time: 1 h Method: Cells with or without the overexpression of PTP1B are seeded at a density of 1 x 10 cells/well on 6-well plates and cultured for 24 h and then for 6 h in serumfree DMEM. Cells are cultured in the presence or absence of KY226 for 1 h, followed by an incubation with insulin for 10 min.Cells are washed and then used for various assays.

参考文献：

1. Yuma Ito, et al. J Pharmacol Sci. 2018 May;137(1):38-46.

溶解性：

Soluble in DMSO、Ethanol

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.076 ml	10.381 ml	20.761 ml
5 mM	0.415 ml	2.076 ml	4.152 ml
10 mM	0.208 ml	1.038 ml	2.076 ml
50 mM	0.042 ml	0.208 ml	0.415 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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