货号	规格	价格	上海	北京	珠海	重庆	武汉
S88452-2mg买3赠1	99.50%	￥216.00 S88452-2mg ￥216.00 现货（买3赠1）	2 4 2	2	2	-	-
S88452-5mg买3赠1	99.50%	￥305.00 S88452-5mg ￥305.00 现货（买3赠1）	11 >10	-	-	-	-
S88452-10mg买3赠1	99.50%	￥560.00 S88452-10mg ￥560.00 现货（买3赠1）	4 4	-	-	-	-
S88452-25mg买3赠1	99.50%	￥780.00 S88452-25mg ￥780.00 现货（买3赠1）	5 5	-	-	-	-
S88452-50mg买3赠1	99.50%	￥1450.00 S88452-50mg ￥1450.00 现货（买3赠1）	4 4	-	-	-	-
S88452-100mg买3赠1	99.50%	￥2350.00 S88452-100mg ￥2350.00 现货（买3赠1）	5 5	-	-	-	-

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产品描述：

SRI-011381是一种新型的TGF-beta信号通路激动剂，用来治疗阿尔茨海默病

靶点：

TGF-β;TGF-beta/Smad

体内研究：

SRI-011381, a small-molecule agonist of TGFβ signaling, has no effect on outflow tract (OFT) expansion in zebrafish, suggesting that hyperactivation of TGFβ signaling is not sufficient to induce aneurysm

细胞实验：

Cell lines: pulmonary fibroblasts of silicosis mouse model Concentrations: 10 µM Incubation Time: -- Method: The tissues are extracted in a sterile environment, rinsed in PBS 3 times, and then cut into 1-mm3 tissue blocks. After repeated digestion with 0.25% trypsin at 37 ℃, the histolysate is evenly spread in a 10-cm petri dish. A high-glucose medium containing 10% fetal bovine serum, penicillin, and streptomycin is added to the petri dish. The cells are cultured in an incubator, and the medium is exchanged every 2-3 days. When the cells reached 80-90% confluence, they are passaged according to the ratio of 1: 3, and the fifth passage cells are taken for experimental study. Pulmonary fibroblasts are identified using anti-vimentin antibody with fluorescent secondary antibodies under a fluorescence microscope. For in vitro experiments, a range of concentrations of SF solution (0.04, 0.1, 0.18 and 0.28 mg/mL) are prepared for the treatment of fibroblasts. A 10 μM SRI-011381 solution is used for the activati

动物实验：

Animal Models: Zebrafish carrying ltbp3fb28 and ltbp1fb29 Dosages: 500 µM Administration: exposed

参考文献：

1. Hu L,et al.Exp Eye Res. 2019;182:44-56. 2. Han, Jingyin et al. Medical science monitor : international medical journal of experimental and clinical research vol. 27 e927978. 15 Jun. 2021, 3. Abrial M, et al. Dis Model Mech. 2022 Mar 1;15(3):dmm046979.

溶解性：

Soluble in DMSO、Ethanol

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.035 ml	15.175 ml	30.351 ml
5 mM	0.607 ml	3.035 ml	6.07 ml
10 mM	0.304 ml	1.518 ml	3.035 ml
50 mM	0.061 ml	0.304 ml	0.607 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

SRI-011381

N'-Cyclohexyl-N-(phenylmethyl)-N-(4-piperidinylmethyl)-urea

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)