| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S88454-1mg买3赠1 |
≥98% | ￥520.00 |
>10 | - | - | - | - |
|
S88454-5mg买3赠1 |
≥98% | ￥990.00 |
>10 | - | - | - | - |
|
S88454-10mg买3赠1 |
≥98% | ￥1590.00 |
>10 | - | - | - | - |
|
S88454-25mg买3赠1 |
≥98% | ￥2730.00 |
>10 | - | - | - | - |
|
S88454-50mg买3赠1 |
≥98% | ￥3830.00 |
10 | - | - | - | - |
|
S88454-100mg |
≥98% | ￥5170.00 |
5 | - | - | - | - |
|
| 产品描述： | FT113 is a potent and orally active fatty acid synthase (FASN) inhibitor, with an IC50 of 213 nM for full-length recombinant human FASN enzyme. In cell-based assay, FT113 blocks FASN activity in BT474 cells (IC50, 90 nM). FT113 shows anti-proliferative activity, and exhibits anti-cancer activity both in vitro and in vivo |
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| 靶点： | IC50: 213 nM (FASN), 90 nM (FASN, in BT474 cell);FattyAcidSynthase | ||||||||||||||||||||
| 体内研究： | FT113 (5 mg/kg, p.o.) exhibits potent oral bioavailability of 95% and 84% in mice and rats, respectively. FT113 (5, 25, or 50 mg/kg, p.o., twice daily for 16 days) increases malonyl-CoA concentration in tumors, inhibits tumor growth in a dose-dependent manner in mice. Animal Model: Athymic nude mice bearing MV-411 cells[1] Dosage: 5, 25, or 50 mg/kg Administration: P.O., twice daily for 16 days Result: Caused 32 % and 50% tumor growth inhibition at 25 and 50 mg/kg, respectively in mice. | ||||||||||||||||||||
| 参考文献： | 1. Martin MW, et al. Discovery and optimization of novel piperazines as potent inhibitors of fatty acid synthase (FASN). Bioorg Med Chem Lett. 2019 Apr 15;29(8):1001-1006. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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