| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S88491-500ug促销 |
≥98% | ￥224.00 ￥170.00 |
10 | - | - | - | - |
|
S88491-1mg促销 |
98.30% | ￥359.00 ￥280.00 |
5 | - | 2 | - | - |
|
S88491-5mg促销 |
98.30% | ￥944.00 ￥750.00 |
5 | - | - | - | - |
|
S88491-10mg买3赠1 |
98.30% | ￥1350.00 ￥1080.00 |
6 | - | - | - | - |
|
S88491-25mg买3赠1 |
98.30% | ￥3010.00 ￥2700.00 |
6 | - | - | - | - |
|
S88491-50mg买3赠1 |
98.30% | ￥4340.00 ￥3900.00 |
5 | - | - | - | - |
|
S88491-100mg促销 |
98.30% | ￥7720.00 ￥6940.00 |
5 | - | - | - | - |
|
| 产品描述： | MZ-1 是一种 bromodomain-containing protein 4 (BRD4) 的PROTAC降解剂。MZ-1 可结合到Brd结构域Brd2BD1、Brd2BD2、Brd3BD1、Brd3BD2、Brd4BD1和Brd4BD2，对应的Kd值分别为62 nM、60 nM、21 nM、13 nM、39 nM和15 nM |
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| 靶点： | Brd3(BD2)(Cell-free assay):13 nM(Kd); Brd4(BD2)(Cell-free assay):15 nM(Kd); Brd3(BD1)(Cell-free assay):21 nM(Kd); Brd4(BD1)(Cell-free assay):39 nM(Kd); Brd2(BD2)(Cell-free assay):60 nM(Kd);Brd2(BD1):62 nM(Kd);EpigeneticReaderDomain | ||||||||||||||||||||
| 体外研究： | MZ-1 induces apoptosis of ovarian cancer cells and inhibits periostin-mediated ovarian cancer cell migration and invasion in vitro. MZ-1 specifically and efficiently inhibits the colony formation of periostin cells in soft agar, which clearly indicates a proproliferation role of periostin | ||||||||||||||||||||
| 体内研究： | Our in vivo studies shows significant growth inhibition by MZ-1 on both subcutaneous and intraperitoneal (i.p.) tumors derived from the periostin-expressing ovarian cancer cell line A2780. In addition, MZ-1 treatment leads to a reduction of the metastatic potential of these A2780 i.p. tumors. The in vivo antitumor effects of MZ-1 are linked to its specific inhibition of anchorage-independent growth and survival of periostin-expressing cells, as well as its neutralizing effects on periostin-induced cancer cell migration and invasion | ||||||||||||||||||||
| 细胞实验： | Cell lines: A2780, OAW-42, SKOV-3, TOV-112D, ES2, SP2/0 cell line Concentrations: 20 μM Incubation Time: 2 and 4 days Method: In vitro apoptosis assay: Cells are grown in 24-well plates in serum-free medium (SFM) plus 1% BSA overnight to reach 50% to 60% confluency. A portion of 20 mg/mL of MZ-1 or control antibody is added into the wells. Cell apoptosis is analyzed 2 and 4 days later by using Annexin V-FITC Apoptosis Detection Kit. The cell flow cytometry is carried on Cell LabQuanta SC. | ||||||||||||||||||||
| 动物实验： | Animal Models: Female SCID beige mice (6-8 weeks old) with A2780/TOV-112D xenografts Dosages: 20 mg/kg Administration: IH/SC, IP | ||||||||||||||||||||
| 参考文献： | 1. Morgan S Gadd, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521. 2. Min Zhu, et al. Neutralizing monoclonal antibody to periostin inhibits ovarian tumor growth and metastasis. Mol Cancer Ther. 2011 Aug;10(8):1500-8. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、Ethanol | ||||||||||||||||||||
| 保存条件： | -20°C | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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营业执照(三证合一)
北京