货号	规格	价格	上海	北京	珠海	重庆	武汉
S88511-1mg买3赠1	99.20%	￥1000.00 S88511-1mg ￥1000.00 现货（买3赠1）	8 8	-	-	-	-
S88511-5mg买3赠1	99.20%	￥2400.00 S88511-5mg ￥2400.00 现货（买3赠1）	6 6	-	-	-	-
S88511-10mg买3赠1	99.20%	￥3800.00 S88511-10mg ￥3800.00 现货（买3赠1）	5 5	-	-	-	-
S88511-25mg	99.20%	￥8000.00 S88511-25mg ￥8000.00 现货	6 6	-	-	-	-

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产品描述：

Sulfatinib (Surufatinib) is a potent and highly selective tyrosine kinase inhibitor against VEGFR1/2/3, FGFR1 and CSF1R with IC50s of in a range of 1 to 24 nM.

靶点：

VEGFR1;VEGFR2;VEGFR3;FGFR1;CSF1R

体外研究：

Sulfatinib inhibits VEGFR1, 2, and 3, FGFR1 and CSF1R kinases with IC50s in a range of 1 to 24 nM, and it strongly blocks VEGF induced VEGFR2 phosphorylation in HEK293KDR cells and CSF1 stimulated CSF1R phosphorylation in RAW264.7 cells with IC50 of 2 and 79 nM, respectively. Sulfatinib also attenuates VEGF or FGF stimulated HUVEC cells proliferation with IC50< 50 nM. Also, it is a hERG inhibitor with IC50 of 6.8 μM in CHO cell

体内研究：

In animal studies, a single oral dosing of Sulfatinib inhibits VEGF stimulated VEGFR2 phosphorylation in lung tissues of nude mice in an exposure-dependent manner. Furthermore, elevation of FGF23 levels in plasma 24 hours post dosing suggests suppression of FGFR signaling. Sulfatinib demonstrates potent tumor growth inhibition in multiple human xenograft models and decreases CD31 expression remarkably, suggesting strong inhibition on angiogenesis through VEGFR and FGFR signaling. In a syngeneic murine colon cancer model CT-26, Sulfatinib demonstrates moderate tumor growth inhibition after single agent treatment. After oral dosing of 10 mg/kg, the AUC and Cmax are 397 ng/mL and 138ng/mL in the mouse, respectively

参考文献：

1. PCT Int. Appl. (2011), WO 2011060746 A1 20110526.

溶解性：

Soluble in DMSO

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.081 ml	10.404 ml	20.808 ml
5 mM	0.416 ml	2.081 ml	4.162 ml
10 mM	0.208 ml	1.04 ml	2.081 ml
50 mM	0.042 ml	0.208 ml	0.416 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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