| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S88515-2mg促销 |
99% | ￥412.00 ￥230.00 |
5 | - | - | - | - |
|
S88515-5mg促销 |
99% | ￥926.00 ￥520.00 |
7 | - | - | - | - |
|
S88515-25mg促销 |
99% | ￥3090.00 ￥1510.00 |
10 | - | - | - | - |
|
S88515-100mg促销 |
99% | ￥8240.00 ￥3110.00 |
8 | - | - | - | - |
|
| 产品描述： | SBI-0640756 (SBI-756) is an inhibitor of eIF4G1 and disrupts the eIF4F complex. | ||||||||||||||||||||
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| 靶点： | eIF4G1;PERK; Autophagy | ||||||||||||||||||||
| 体外研究： | SBI-0640756 (SBI-756) is a water soluble inhibitor of eIF4G1. SBI-0640756 (SBI-756) (0-1 μM) disrupts eIF4F complex in parent and BRAFi-resistant melanoma. SBI-0640756 (SBI-756) shows inhibitory effect on human melanoma lines, and also suppresses AKT, NF-κB and AKT/mTORC1 activity | ||||||||||||||||||||
| 体内研究： | SBI-0640756 (SBI-756) (0.5 mg/kg, i.p.) delays tumor onset and reduces tumor incidence by 50% in NrasQ61K/Ink4a–/– genetic model. SBI-0640756 (SBI-756) (1 mg/kg, 2 times per week, i.p.) in combination with BRAF inhibitor potently suppresses growth of established tumors and does not resume tumor growth in immunodeficient mice bearing A375 tumors | ||||||||||||||||||||
| 参考文献： | 1. Feng Y et al. SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex. Cancer Res, 2015 Dec 15, 75(24):5211-8. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20°C | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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