| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S88558-1mg买3赠1 |
98.20% | ￥200.00 |
8 | - | - | - | - |
|
S88558-5mg买3赠1 |
98.20% | ￥450.00 |
6 | - | - | - | - |
|
S88558-10mg买3赠1 |
98.20% | ￥600.00 |
9 | - | - | - | - |
|
S88558-25mg买3赠1 |
98.20% | ￥1120.00 |
1 | - | - | - | - |
|
S88558-50mg买3赠1 |
≥98% | ￥1870.00 |
货期：2-3天 | - | - | - | - |
|
S88558-100mg买3赠1 |
≥98% | ￥3370.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | WM-1119 is a highly potent and selective KAT6A inhibitor, with an IC50 of 0.25 μM for KAT6A in lymphoma cells, the binding KD values of WM-1119 with KAT6A, KAT5 and KAT7 are 2 nM, 2.2 μM, 0.5 μM , respectively | ||||||||||||||||||||
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| 靶点： | IC50: 0.25 μM (KAT6A in lymphoma cells), KD: 2 nM (KAT6A), 2.2 μM (KAT5), 0.5 μM (KAT7);HistoneAcetyltransferase | ||||||||||||||||||||
| 体外研究： | WM-1119 induces cell cycle exit and cellular senescence without causing DNA damage. WM-1119 is 1,100-fold and 250-fold more active against KAT6A than against KAT5 or KAT7, respectively, and so shows greater specificity for KAT6A than does WM-8014. Treatment of MEFs with WM-1119 results in cell cycle arrest in G1 and a senescence phenotype similar to that seen upon treatment with WM-8014. Notably, the activity of WM-1119 in this cell-based assay is an order of magnitude greater than WM-8014 and WM-1119 is able to induce cell cycle arrest at 1 μM. Treatment with WM-1119 inhibits the proliferation of the EMRK1184 lymphoma cells in vitro, WM-1119 (IC50=0.25 μM) is ninefold more active than WM-8014 (IC50=2.3 μM), as expected on the basis of reduced protein binding | ||||||||||||||||||||
| 体内研究： | By day 14, the cohorts that are treated four times per day with WM-1119 have arrested tumour growth, with the exception of one mouse that does not respond. Spleen weights in the WM-1119-treatment group (treated four times per day) are substantially lower than spleen weights in the vehicle-treated group. Treatment with WM-1119 three times per day leads to a significant reduction in tumour burden and spleen weight, but is not as effective as treatment four times per day. WM-1119 is well-tolerated; mice show no generalized ill effects and weight loss is not observed. The proportion and overall number of tumour cells is substantially reduced by WM-1119 treatment (four times per day) | ||||||||||||||||||||
| 参考文献： | 1. Baell JB et al. Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth. Nature. 2018 Aug;560(7717):253-257. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20°C | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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