货号	规格	价格	上海	北京	珠海	重庆	武汉
S88567-1mg买3赠1	98.60%	￥220.00 S88567-1mg ￥220.00 现货（买3赠1）	6 6	-	-	-	-
S88567-5mg买3赠1	98.60%	￥400.00 S88567-5mg ￥400.00 现货（买3赠1）	4 4	-	-	-	-
S88567-10mg买3赠1	98.60%	￥680.00 S88567-10mg ￥680.00 现货（买3赠1）	5 5	-	-	-	-
S88567-25mg买3赠1	98.60%	￥1360.00 S88567-25mg ￥1360.00 现货（买3赠1）	5 5	-	-	-	-
S88567-50mg买3赠1	98.60%	￥2560.00 S88567-50mg ￥2560.00 现货（买3赠1）	4 4	-	-	-	-
S88567-100mg买3赠1	98.60%	￥4160.00 S88567-100mg ￥4160.00 现货（买3赠1）	2 2	-	-	-	-

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产品描述：

SR-18292 is a PPAR gamma coactivator-1α (PGC-1α) inhibitor, which increases PGC-1α acetylation, suppresses gluconeogenic gene expression and reduces glucose production in hepatocytes.

靶点：

PGC-1α;Autophagy

体外研究：

The transcriptional coactivator PGC-1α plays a pivotal role in energy homeostasis by co-activating transcription factors that regulate fat and glucose metabolism. SR-18292 increases the interaction of PGC-1α with the acetyl transferase GCN5 and reduces co-activation of nuclear hormone receptor HNF4α by PGC-1α. SR-18292 suppresses HNF4α/PGC-1α gluconeogenic transcriptional function. By increasing the interaction of GCN5 with PGC-1α, SR-18292 increases the acetylation of specific PGC-1α lysine residues that might subsequently decrease its gluconeogenic activity.

体内研究：

SR-18292 reduces fasting blood glucose, increases hepatic insulin sensitivity and improves glucose homeostasis in diabetic mice. The high fat diet (HFD) fed mice, a dietary model of obesity and T2D, are treated with SR-18292 (45mg/kg) via I.P. injection for 3 consecutive days and again on day 4 before measuring fasting blood glucose. Strikingly, mice that are treated with SR-18292 have significantly lower levels of fasting blood glucose concentrations compared to matched vehicle-treated control mice. The induction of gluconeogenic gene expression is a regulatory component of the response to fasting. Importantly, gluconeogenic gene expression, specifically that of Pck1, is inhibited in livers isolated from mice treated with SR-18292.

参考文献：

1. Sharabi K, et al. Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes. Cell. 2017 Mar 23;169(1):148-160.e15.

溶解性：

Soluble in DMSO、Ethanol

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.729 ml	13.643 ml	27.285 ml
5 mM	0.546 ml	2.729 ml	5.457 ml
10 mM	0.273 ml	1.364 ml	2.729 ml
50 mM	0.055 ml	0.273 ml	0.546 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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