| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S88577-5mg买3赠1 |
99.30% | ￥400.00 |
6 | - | - | - | - |
|
S88577-10mg买3赠1 |
99.30% | ￥640.00 |
6 | - | - | - | - |
|
S88577-25mg促销 |
99.30% | ￥1120.00 ￥896.00 |
6 | - | - | - | - |
|
S88577-50mg促销 |
≥98% | ￥1760.00 ￥1400.00 |
货期：2-3天 | - | - | - | - |
|
S88577-100mg促销 |
≥98% | ￥3040.00 ￥2430.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | WNK-IN-11 is an allosteric With-No-Lysine (WNK) kinase inhibitor, with an IC50 of 4 nM for WNK1. | ||||||||||||||||||||
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| 靶点： | IC50: 4 nM (WNK1);Serine/threoninkinase | ||||||||||||||||||||
| 体外研究： | WNK-IN-11 (compound 11) shows IC50<2 μM in the cellular OSR1 phosphorylation assay with reasonable aqueous solubility, albeit with still rather high microsomal clearance. WNK-IN-11 shows ATP noncompetitive inhibition. When tested against a panel of 440 human kinases at 10 μM concentration, 2500-fold above enzyme IC50 value, WNK-IN-11 shows excellent selectivity with only a few significant off-target kinase inhibitions, most notably BTK and feline encephalitis virus-related (FER) kinase, neither of which are implicated for blood pressure regulation. This excellent selectivity profile is consistent with the predicted allosteric binding mode outside the highly conserved ATP-pocket | ||||||||||||||||||||
| 参考文献： | 1. Yamada K, et al. Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models. J Med Chem. 2017 Aug 24;60(16):7099-7107. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20°C | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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