| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S88580-1mg买3赠1 |
98.90% | ￥250.00 |
9 | - | - | - | - |
|
S88580-5mg买3赠1 |
98.90% | ￥750.00 |
6 | - | - | - | - |
|
S88580-10mg促销 |
98.90% | ￥1200.00 ￥960.00 |
5 | - | - | - | - |
|
S88580-25mg促销 |
98.90% | ￥2360.00 ￥1880.00 |
5 | - | - | - | - |
|
S88580-50mg促销 |
≥98% | ￥4260.00 ￥3400.00 |
货期：2-3天 | - | - | - | - |
|
S88580-100mg促销 |
≥98% | ￥6700.00 ￥5360.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | R-IMPP (PF-00932239) is an anti-secretagogue of PCSK9 (IC50=4.8 μM), which targets the 80S ribosome to inhibit PCSK9 protein translation | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | IC50: 4.8 μM (PCSK9);Serine/threoninkinase | ||||||||||||||||||||
| 体外研究： | R-IMPP stimulates uptake of LDL-C in hepatoma cells by increasing LDL-R levels, without altering levels of secreted transferrin. R-IMPP does not decrease PCSK9 transcription or increase PCSK9 degradation, but causes transcript-dependent inhibition of PCSK9 translation. R-IMPP is able to selectively bind to human, but not E. coli, ribosomes | ||||||||||||||||||||
| 参考文献： | 1. Petersen DN, et al. A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation. Cell Chem Biol. 2016 Nov 17;23(11):1362-1371 | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20°C | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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北京