货号	规格	价格	上海	北京	珠海	重庆	武汉
S88591-2mg促销	≥98%	￥282.00 ￥254.00 S88591-2mg ￥254.00 2-3天	0 货期：2-3天	-	-	-	-
S88591-5mg	≥98%	￥366.00 S88591-5mg ￥366.00 2-3天	0 货期：2-3天	-	-	-	-
S88591-10mg	≥98%	￥621.00 S88591-10mg ￥621.00 现货	10 0 10	-	-	-	-
S88591-25mg	≥98%	￥1318.00 S88591-25mg ￥1318.00 现货	6 6	-	-	-	-
S88591-50mg促销	≥98%	￥2480.00 ￥2240.00 S88591-50mg ￥2240.00 现货	4 4	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

RK-287107 是一种新型有效且具有选择性及抗肿瘤活性的 tankyrase 的抑制剂。RK-287107 可抑制 tankyrase-1 和 tankyrase-2，在体外实验中其IC50值为14.3 nM和10.6 nM

靶点：

Tankyrase-2(Cell-free assay):10.6 nM; Tankyrase-1(Cell-free assay):14.3 nM;PARP

体外研究：

RK-287107 is a novel tankyrase-specific inhibitor that inhibits tankyrase-1 and -2. RK-287107 causes Axin2 accumulation and downregulates β-catenin, T-cell factor/lymphoid enhancer factor reporter activity and the target gene expression in colorectal cancer cells harboring the shortly truncated APC mutations. Consistently, RK-287107 inhibits the growth of APC-mutated (β-catenin-dependent) colorectal cancer COLO-320DM and SW403 cells but not the APC-wild (β-catenin-independent) colorectal cancer RKO cells

体内研究：

Intraperitoneal or oral administration of RK-287107 suppresses COLO-320DM tumor growth in NOD-SCID mice. RK-287107 suppresses the Wnt/β-catenin pathway and tumor growth of the xenografted COLO-320DM cells in vivo

细胞实验：

Cell lines: COLO-320DM, HCC2998, HCT-116, DLD-1, SW403, RKO Concentrations: 0.01-10 μM Incubation Time: 120 h Method: Cells are treated with RK-287107 in triplicate for 120 h. Relative cell number is quantitated by MTT assays. Experiments are repeated at least twice and the average values are plotted.

动物实验：

Animal Models: 6-week-old female NOD.CB17-Prkdcscid/J mice s.c. injected with COLO-320DM cells Dosages: 100 mg/kg, 150 mg/kg, 300 mg/kg Administration: IP, Oral gavage

参考文献：

1. Mizutani A, et al. RK-287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model. Cancer Sci. 2018 Dec;109(12):4003-4014.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.401 ml	12.006 ml	24.012 ml
5 mM	0.48 ml	2.401 ml	4.802 ml
10 mM	0.24 ml	1.201 ml	2.401 ml
50 mM	0.048 ml	0.24 ml	0.48 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置