货号	规格	价格	上海	北京	珠海	重庆	武汉
S88609-1mg买3赠1	99.90%	￥160.00 S88609-1mg ￥160.00 现货（买3赠1）	9 9	-	-	-	-
S88609-5mg	99.90%	￥260.00 S88609-5mg ￥260.00 现货	6 6	-	-	-	-
S88609-10mg	99.90%	￥410.00 S88609-10mg ￥410.00 现货	6 6	-	-	-	-
S88609-25mg	99.90%	￥830.00 S88609-25mg ￥830.00 现货	3 3	-	-	-	-
S88609-50mg	≥98%	￥1340.00 S88609-50mg ￥1340.00 2-3天	0 货期：2-3天	-	-	-	-
S88609-100mg	≥98%	￥2140.00 S88609-100mg ￥2140.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

Etrumadenant (AB928, A2aR/A2bR antagonist-1)是一种新型的 A2aR/A2bR 的双重活性拮抗剂，对于A2aR和A2bR的Kd值分别为1.4 nM和2 nM

靶点：

A2AR(Cell-free assay):1.4 nM(Kd); A2bR(Cell-free assay):2 nM(Kd);AdenosineReceptor

体外研究：

Consistent with the ability of adenosine to suppress immune function, AB928 inhibits the ability of adenosine to suppress CD4 or CD8 T cell activation

体内研究：

Established AT-3-OVA tumors treated with AB928 alone has a small but significant decrease in their growth rate. Concurrent treatment with AB928 and chemotherapy results in significantly reduced tumor growth rates, when compared to chemotherapy alone

细胞实验：

Cell lines: CD4+ T cells, CD8+ T cells Concentrations: 1 nM, 3 nM, 10 nM, 30 nM Incubation Time: -- Method: CD4+ or CD8+ T cells are isolated from PBMC using RosetteSep separation and are stimulated with CD2/CD3/CD28 microbeads +/- adenosine/EHNA +/- AB928. Human CD14+ cells are differentiated into moDC for 6 days in IL-4/GM-CSF +/- adenosine/EHNA, +/- AB928. Adenosine is present during moDC activation via IFN-y or LPS. Cells are washed in excess buffer, to remove residual adenosine, prior to setting up the mixed leukocyte reaction (MLR). Supernatants are collected 4 days after initiation of the moDC/CD4 co-culture.

动物实验：

Animal Models: female C57BL/6 mice Dosages: 100 mg/kg Administration: Oral gavage

参考文献：

1. Lisa Seitz, et al. Safety, tolerability, and pharmacology of AB928, a novel dual adenosine receptor antagonist, in a randomized, phase 1 study in healthy volunteers. Invest New Drugs. 2019 Aug;37(4):711-721. 2. Walters MJ, et al. Abstract 5556: Combining adenosine receptor inhibition with AB928 and chemotherapy results in greater immune activation and tumor control. Cancer Res 2018;78(13 Suppl):Abstract nr 5556.

溶解性：

Soluble in DMSO、Ethanol

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.345 ml	11.724 ml	23.448 ml
5 mM	0.469 ml	2.345 ml	4.69 ml
10 mM	0.234 ml	1.172 ml	2.345 ml
50 mM	0.047 ml	0.234 ml	0.469 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

AB-928

AB 928

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)