货号	规格	价格	上海	北京	珠海	重庆	武汉
S88615-5mg买3赠1	99.10%	￥390.00 S88615-5mg ￥390.00 现货（买3赠1）	4 4	-	-	-	-
S88615-10mg买3赠1	99.10%	￥620.00 S88615-10mg ￥620.00 现货（买3赠1）	6 6	-	-	-	-
S88615-25mg促销	99.10%	￥1050.00 ￥840.00 S88615-25mg ￥840.00 现货	5 5	-	-	-	-
S88615-50mg促销	≥98%	￥1570.00 ￥1250.00 S88615-50mg ￥1250.00 2-3天	0 货期：2-3天	-	-	-	-
S88615-100mg促销	≥98%	￥2370.00 ￥1890.00 S88615-100mg ￥1890.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

UAMC-3203 is a potent and selective Ferroptosis inhibitor (IC50: 12 nM).

靶点：

Ferroptosis

体外研究：

UAMC-3203 exhibits even lower IC50-values (10 nM in IMR32 Neuroblastoma cells.) combined with an excellent kinetic solubility (> 200 μM).

体内研究：

In blood plasma of mice having received a daily injection of compound UAMC-3203 over a period of 4 weeks, Plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST), LDH, creatine kinase (CK), creatinine, urea and troponin T levels were all comparable to background values detected in control mice.

细胞实验：

In order to determine IC50-values, human neuroblastoma cells (IMR-32) were seeded in a 96-well plate at a density of 25,000 cells/well. The next day, the cells were pretreated for 1h (in triplicates) with a 1/3 dilution series of ferrostatin-1 analogues ranging from 5μM to 0.68nM and Sytox Green (1.6 μM) and a 1/2 dilution series of ferrostatin-1 analogues ranging from 200 nM to 0.78nM and Sytox Green (1.6 μM) for erastin and ferrous ammonium sulphate respectively. After stimulating the cells with erastin (10 μM) or ferrous ammonium sulphate (600 μM), the plate was transferred to a temperature- and CO2-controled FLUOstar Omega fluorescence plate reader. Sytox Green intensity was measured after 13h using an excitation filter of 485 nm and an emission filter of 520 nm. In each setup, Triton-X100 (0.05%) was used to induce lyses of the cells in 6 wells/plate, and was used as 100% cell death reference. The percentage of the cell death was calculated by the formula ((AVG[erastin] - AVG[background]) /(AVG[Triton-X1

动物实验：

Vehicle solution (2% DMSO) or compound was administered daily at a concentration of 2 mM (in 0.9% NaCl containing 2% DMSO; 200 μL / 20 g body weight) by intraperitoneal injection. Body temperature and weight were monitored daily. On day 28 the mice were anesthetized with isoflurane and blood was sampled. Hereafter, mice were sacrificed by cervical dislocation. ALT, AST and LDH levels in plasma were measured. CK, creatinine, urea and troponin T were determined.

参考文献：

1. Devisscher L, et al. Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy. J Med Chem. 2018 Nov 21;61(22):10126-10140.

溶解性：

Soluble in DMSO

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.12 ml	10.601 ml	21.202 ml
5 mM	0.424 ml	2.12 ml	4.24 ml
10 mM	0.212 ml	1.06 ml	2.12 ml
50 mM	0.042 ml	0.212 ml	0.424 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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