货号	规格	价格	上海	北京	珠海	重庆	武汉
S88622-5mg买3赠1	99.40%	￥256.00 S88622-5mg ￥256.00 现货（买3赠1）	3 3	-	-	-	-
S88622-10mg买3赠1	99.40%	￥460.00 S88622-10mg ￥460.00 现货（买3赠1）	3 3	-	-	-	-
S88622-25mg买3赠1	99.40%	￥970.00 S88622-25mg ￥970.00 现货（买3赠1）	3 3	-	-	-	-
S88622-50mg买3赠1	99.40%	￥1550.00 S88622-50mg ￥1550.00 现货（买3赠1）	4 4	-	-	-	-
S88622-100mg买3赠1	≥98%	￥2300.00 S88622-100mg ￥2300.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

Adagrasib (MRTX849) 是一种有效的，选择性的和共价的KRAS G12C抑制剂，具有良好的药物样特性，可选择性地修饰GDP结合的KRAS G12C中的突变半胱氨酸12并抑制KRAS依赖性信号传导

靶点：

K-Ras(G12C);Ras

体外研究：

To evaluate the breadth of MRTX849 activity, its effect on cell viability is determined across a panel of 17 KRASG12C-mutant and three non-KRASG12C-mutant cancer cell lines using 2D (3-day, adherent cells) and 3D (12-day, spheroids) cell growth conditions. MRTX849 potently inhibits cell growth in the vast majority of KRASG12C-mutant cell lines with IC50 values ranging between 10 nM and 973 nM in the 2D format and between 0.2 nM and 1042 nM in the 3D format

体内研究：

Rapid tumor regression is observed at the earliest posttreatment tumor measurement and animals in the 30 mg/kg and 100 mg/kg cohorts exhibits evidence of a complete response at study Day 15. Dosing is stopped at study Day 16 and all 4 mice in the 100 mg/kg cohort and 2 out of 7 mice in the 30 mg/kg cohort remains tumor-free through study Day 70

细胞实验：

Cell lines: MIA PaCa-2, H1373, H358, H2122, SW1573, H2030, KYSE-410 cells (G12C); H1299 (WT); A549 (G12S), HCT116 (G13D) cells Concentrations: -- Incubation Time: 24 h Method: All cell lines were maintained at 37 ℃ in a humidified incubator at 5% CO2 and were periodically checked for mycoplasma. CellTiter-Glo assay to evaluate cell viability performed on seven KRAS G12C-mutant cell lines and three non-KRAS G12C-mutant cell lines cells grown in 2D tissue culture conditions in a 3-day assay or 3D conditions using 96-well, ULA plates in a 12-day assay.

动物实验：

Animal Models: MIA PaCa-2 model Dosages: 3 mg/kg, 10 mg/kg, 30 mg/kg and 100 mg/kg Administration: Oral gavage

参考文献：

1. Jill Hallin,et al. The KRASG12C Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients. Cancer Discov.2020;10 (1): 54-71.

溶解性：

Soluble in DMSO、Ethanol

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.655 ml	8.277 ml	16.553 ml
5 mM	0.331 ml	1.655 ml	3.311 ml
10 mM	0.166 ml	0.828 ml	1.655 ml
50 mM	0.033 ml	0.166 ml	0.331 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

MRTX-849

2-PIPERAZINEACETONITRILE, 4-[7-(8-CHLORO-1-NAPHTHALENYL)-5,6,7,8-TETRAHYDRO-2-[[(2S)-1-METHYL-2-PYRR

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)