| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S88629-5mg促销 |
≥98%(HPLC) | ￥584.00 ￥460.00 |
10 | - | - | - | - |
|
S88629-10mg促销 |
≥98%(HPLC) | ￥986.00 ￥780.00 |
10 | - | - | - | - |
|
S88629-25mg促销 |
≥98%(HPLC) | ￥2330.00 ￥1860.00 |
10 | - | - | - | - |
|
S88629-50mg促销 |
≥98%(HPLC) | ￥4200.00 ￥3360.00 |
2 | - | - | - | - |
|
S88629-100mg促销 |
≥98%(HPLC) | ￥7570.00 ￥6050.00 |
2 | - | - | - | - |
|
S88629-250mg促销 |
≥98%(HPLC) | ￥13200.00 ￥10600.00 |
1 | - | - | - | - |
|
| 产品描述： | PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (JARID1) enzymes. PBIT inhibits JARID1B (KDM5B or PLU1) histone demethylase with an IC50 of about 3 μM . PBIT also inhibits JARID1A and JARID1C with IC50s of 6 μM and 4.9 μM, respectively | ||||||||||||||||||||
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| 靶点： | IC50: 3 μM (JARID1B), 6 μM (JARID1A), 4.9 μM (JARID1C);HistoneDemethylase; HistoneMethyltransferase | ||||||||||||||||||||
| 体外研究： | PBIT inhibits proliferation of cells expressing higher levels of JARID1B. PBIT (1-10 μM for UACC-812 cells, 2.5-10μM for MCF7 and MCF10A cells; 72 hours) inhibits cell proliferation in a JARID1B level-dependent manner. Cell Proliferation Assay Cell Line: Human breast cancer cell lines (UACC-812 and MCF7) and human mammary epithelial cells (MCF10A) Concentration: 1, 3, and 10 μM for UACC-812 cells; 2.5, 5, and 10 μM for MCF7 and MCF10A cells Incubation Time: 72 hours Result: Inhibited cell proliferation in a JARID1B level-dependent manner. 10 μM killed most of the UACC-812 cells, but showed minimal toxicity to MCF7 cells and MCF10A cells. | ||||||||||||||||||||
| 参考文献： | 1. Sayegh J, et al. Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen. J Biol Chem. 2013 Mar 29;288(13):9408-17. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20°C | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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营业执照(三证合一)
北京