| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S88641-2mg买3赠1 |
98.40% | ￥238.00 |
3 | - | - | - | - |
|
S88641-5mg买3赠1 |
98.40% | ￥352.00 |
4 | - | - | - | - |
|
S88641-10mg买3赠1 |
98.40% | ￥680.00 |
5 | - | - | - | - |
|
S88641-25mg买3赠1 |
98.40% | ￥1290.00 |
5 | - | - | - | - |
|
S88641-50mg买3赠1 |
≥98% | ￥2380.00 |
货期：2-3天 | - | - | - | - |
|
S88641-100mg买3赠1 |
≥98% | ￥4200.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | R-7050是一种具有细胞透性的TNF-α受体拮抗剂，对TNF-α所介导的信号通路的选择性是对IL-1β驱动的信号的2.3倍 | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | TNF-α:0.63 μM(EC50); IL-1β:1.45 μM(EC50);TNF | ||||||||||||||||||||
| 体外研究： | R-7050 has a clear selectivity toward TNFα and to a slightly weaker extent toward the LPA receptor which belongs to a GPCR class over IL-1β, tyrosine kinase, or Fas receptor systems | ||||||||||||||||||||
| 体内研究： | R-7050 attenuates neurovascular injury after intracerebral hemorrhage (ICH) in mice, Up to 2h post-injury administration of R-7050 significantly reduced blood-brain barrier opening and attenuated edema development at 24h post-ICH. Neurological outcomes were also improved over the first three days after injury. In contrast, R-7050 did not reduce hematoma volume | ||||||||||||||||||||
| 动物实验： | Animal Models: A mouse collagenase model of ICH (based on male CD-1 mice) Dosages: 6–18 mg/kg Administration: IP | ||||||||||||||||||||
| 参考文献： | 1. Melanie D. King, et al. TNF-ALPHA RECEPTOR ANTAGONIST, R-7050, IMPROVES NEUROLOGIAL OUTCOMES FOLLOWING INTRACEREBRAL HEMORRHAGE IN MICE. Neurosci Lett. 2013, 542: 92-96. 2. Gururaja TL, et al. A class of small molecules that inhibit TNFalpha-induced survival and death pathways via prevention of interactions between TNFalphaRI, TRADD, and RIP1. Chem Biol. 2007, 14(10):1105-18. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20°C | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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