| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S88645-5mg买3赠1 |
98.45% | ￥300.00 |
8 | - | - | - | - |
|
S88645-10mg买3赠1 |
98.45% | ￥430.00 |
7 | - | - | - | - |
|
S88645-25mg买3赠1 |
98.45% | ￥800.00 |
1 | - | - | - | - |
|
S88645-50mg买3赠1 |
98.45% | ￥1400.00 |
4 | - | - | - | - |
|
S88645-100mg买3赠1 |
98.45% | ￥2160.00 |
4 | - | - | - | - |
|
| 产品描述： | STING inhibitor C-176是一种有效的STING抑制剂。STING是细胞内DNA感应通路的主要信号分子 | ||||||||||||||||||||
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| 靶点： | STING | ||||||||||||||||||||
| 体外研究： | C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. It directly targets mouse STING (mmSTING) but not human STING (hsSTING) | ||||||||||||||||||||
| 体内研究： | C-176 attenuates STING-associated autoinflammatory disease in mice | ||||||||||||||||||||
| 细胞实验： | Cell lines: H526 cells Concentrations: 1 μM Incubation Time: 48 h Method: Cells were treated 1 μM C176 and 1 μM AZD1775 for 48 h | ||||||||||||||||||||
| 动物实验： | Cell lines: H526 cells Concentrations: 1 μM Incubation Time: 48 h Method: Cells were treated 1 μM C176 and 1 μM AZD1775 for 48 h | ||||||||||||||||||||
| 参考文献： | 1. Haag SM, et al. Targeting STING with covalent small-molecule inhibitors, Nature. 2018, 559(7713):269-273. 2. Taniguchi H, et al. WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC. Cell Rep. 2022 May 17;39(7):110814. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、Ethanol | ||||||||||||||||||||
| 保存条件： | -20°C | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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