货号	规格	价格	上海	北京	珠海	重庆	武汉
S88650-2mg买3赠1	99.90%	￥560.00 S88650-2mg ￥560.00 现货（买3赠1）	5 5	-	-	-	-
S88650-5mg买3赠1	99.90%	￥890.00 S88650-5mg ￥890.00 现货（买3赠1）	5 5	-	-	-	-
S88650-10mg促销	99.90%	￥1390.00 ￥1110.00 S88650-10mg ￥1110.00 现货	5 5	-	-	-	-
S88650-25mg促销	99.90%	￥2380.00 ￥1900.00 S88650-25mg ￥1900.00 现货	5 5	-	-	-	-
S88650-50mg促销	≥98%	￥3450.00 ￥2760.00 S88650-50mg ￥2760.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

3-Methyltoxoflavin is a potent Protein disulfide isomerase (PDI) inhibitor, with an IC50 of 170 nM

靶点：

IC50: 170 nM (PDI)

体外研究：

3-Methyltoxoflavin is a potent Protein disulfide isomerase (PDI) inhibitor, with an IC50 of 170 nM. 3-Methyltoxoflavin is toxic in a panel of human glioblastoma cell lines. From the screen, 3-Methyltoxoflavin emerges as the most cytotoxic inhibitor of PDI. Bromouridine labeling and sequencing (Bru-seq) of nascent RNA reveals that 3-Methyltoxoflavin induces Nrf2 antioxidant response, ER stress response, and autophagy. Specifically, 3-Methyltoxoflavin upregulates heme oxygenase 1 and SLC7A11 transcription and protein expression and represses PDI target genes such as TXNIP and EGR1. Interestingly, 3-Methyltoxoflavin-induced cell death does not proceed via apoptosis or necrosis, but by a mixture of autophagy and ferroptosis

参考文献：

1. Kyani A, et al. Discovery and Mechanistic Elucidation of a Class of Protein Disulfide Isomerase Inhibitors for the Treatment of Glioblastoma. ChemMedChem. 2018 Jan 22;13(2):164-177.

溶解性：

Soluble in DMSO

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	4.827 ml	24.133 ml	48.265 ml
5 mM	0.965 ml	4.827 ml	9.653 ml
10 mM	0.483 ml	2.413 ml	4.827 ml
50 mM	0.097 ml	0.483 ml	0.965 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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计算重置

3-methyl toxoflavin