货号	规格	价格	上海	北京	珠海	重庆	武汉
S88655-5mg促销	99.40%	￥160.00 ￥128.00 S88655-5mg ￥128.00 现货	5 5	-	-	-	-
S88655-10mg促销	99.40%	￥245.00 ￥196.00 S88655-10mg ￥196.00 现货	6 6	-	-	-	-
S88655-25mg促销	99.40%	￥430.00 ￥344.00 S88655-25mg ￥344.00 现货	5 5	-	-	-	-
S88655-100mg促销	≥98%	￥1500.00 ￥1200.00 S88655-100mg ￥1200.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM).

靶点：

TGF-beta/Smad; ALK;ALK; TGF-beta/Smad

细胞实验：

The high-content cytotoxicity assay (kit I) was performed according to the manufacturer’s instructions. HaCaT cells were cultured overnight in black 96-well plates, incubated for 24 h with each compound at different concentrations, and stained with cytotoxicity cocktail. Cells were fixed, washed, and scanned on the Cellomics ArrayScan II platform. Images were analyzed with the Cell Health image analysis algorithm. Cytotoxicity indices were calculated for each of the four parameters (cellular membrane integrity, nuclear fragmentation and density, and lysosomal mass) to indicate the percentage of cells outside of the normal range which was defined using a vehicle-treated reference cell population.

参考文献：

1. Roth GJ, et al. Design, synthesis, and evaluation of indolinones as inhibitors of the transforming growth factor β receptor I (TGFβRI). J Med Chem. 2010 Oct 28;53(20):7287-95.

溶解性：

Soluble in DMSO

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.022 ml	10.109 ml	20.217 ml
5 mM	0.404 ml	2.022 ml	4.043 ml
10 mM	0.202 ml	1.011 ml	2.022 ml
50 mM	0.04 ml	0.202 ml	0.404 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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