| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S88658-5mg买3赠1 |
99.80% | ￥240.00 |
6 | - | - | - | - |
|
S88658-10mg买3赠1 |
99.80% | ￥440.00 |
6 | - | - | - | - |
|
S88658-25mg买3赠1 |
99.80% | ￥960.00 |
6 | - | - | - | - |
|
S88658-50mg买3赠1 |
99.80% | ￥1600.00 |
5 | - | - | - | - |
|
S88658-100mg买3赠1 |
≥98% | ￥2880.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | DC260126 is a potent antagonist of GPR40 (FFAR1). DC260126 dose-dependently inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic acid, oleic acid, palmitoleic acid and lauric acid (IC50: 6.28, 5.96, 7.07, 4.58 μM, respectively)[1]. DC260126 could protect MIN6 β cells from palmitate-induced ER stress and apoptosis | ||||||||||||||||||||
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| 靶点： | Free Fatty Acid Receptor; Apoptosis;Apoptosis; GPR | ||||||||||||||||||||
| 体外研究： | DC260126 reduces GTP-loading and ERK1/2 phosphorylation stimulated by linoleic acid in GPR40-CHO cells, suppresses palmitic acid potentiated glucose-stimulated insulin secretion, and negatively regulates GPR40 mRNA expression induced by oleic acid in Min6 cells | ||||||||||||||||||||
| 参考文献： | 1. Hu H, et al. A novel class of antagonists for the FFAs receptor GPR40. Biochem Biophys Res Commun. 2009;390(3):557-563. 2. Wu J, et al. Inhibition of GPR40 protects MIN6 β cells from palmitate-induced ER stress and apoptosis [published correction appears in J Cell Biochem. 2013 May;114(5):1216]. J Cell Biochem. 2012;113(4):1152-1158. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20°C | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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北京