货号	规格	价格	上海	北京	珠海	重庆	武汉
S88677-1mg	≥98%	￥800.00 S88677-1mg ￥800.00 3-5天	0 货期：3-5天	-	-	-	-
S88677-5mg	≥98%	￥1800.00 S88677-5mg ￥1800.00 3-5天	0 货期：3-5天	-	-	-	-
S88677-10mg	≥98%	￥2800.00 S88677-10mg ￥2800.00 3-5天	0 货期：3-5天	-	-	-	-
S88677-25mg	≥98%	￥4950.00 S88677-25mg ￥4950.00 3-5天	0 货期：3-5天	-	-	-	-
S88677-50mg	≥98%	￥6800.00 S88677-50mg ￥6800.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

SNAP-94847 is a selective and competitive MCH1 receptor (MCH1-R) antagonist (Ki: 2.2 nM). It has anxiolytic and antidepressant activity and reduces food intake in mice.

靶点：

GPR; Melanin-concentrating Hormone Receptor (MCHR);GPR; Melanin-concentratingHormoneReceptor(MCHR)

体外研究：

SNAP-94847 showed a favorable combination of MCH1 receptor affinity (Ki: 2.2 nM) and human R1A receptor (>80-fold) and D2 (>500-fold) selectivity

体内研究：

SNAP-94847 (10 mg/kg, p.o.) had no effect on basal water consumption measured over 2 h: vehicle-treated (2.0 mL); 16g-treated (2.3 mL). MCH-evoked water intake was inhibited significantly by SNAP-94847 at doses of 1.0, 2.5, and 10 mg/kg. BALB/c mice treated for 21 days with fluoxetine or SNAP 94847 (20 mg/kg/day) showed marked increases in quinpirole-induced locomotor activity, with the onset of hyper-locomotion appearing earlier in the time course after SNAP 94847 compared to fluoxetine. Administration of either compound for 7 days was also sufficient to augment the quinpirole response in BALB/c mice. The intra-locus coeruleus and intracerebroventricular injections of melanin-concentrating hormone and chronic injections of corticosterone increased immobility time in the forced swim test and decreased sucrose preference in the sucrose preference test. All these depressive-like behaviors were reversed by an intra-locus coeruleus microinjection of SNAP-94847

参考文献：

1. Ye H, et al. Melanin-Concentrating Hormone (MCH) and MCH-R1 in the Locus Coeruleus May Be Involved in the Regulation of Depressive-Like Behavior. Int J Neuropsychopharmacol. 2018 Dec 1;21(12):1128-1137. 2. Marsteller DA, et al. The MCH1 receptor antagonist SNAP 94847 induces sensitivity to dopamine D2/D3 receptor agonists in rats and mice. Eur J Pharmacol. 2009 Jan 5;602(1):66-72. 3. Chen CA, et al. Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists part 2: A hybrid strategy combining key fragments of HTS hits. J Med Chem. 2007 Aug 9;50(16):3883-90.

溶解性：

Soluble in DMSO

保存条件：

2-8°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.09 ml	10.448 ml	20.896 ml
5 mM	0.418 ml	2.09 ml	4.179 ml
10 mM	0.209 ml	1.045 ml	2.09 ml
50 mM	0.042 ml	0.209 ml	0.418 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

SNAP 94847

N-[3-[1-[[4-(3,4-Difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methylpropanamidehydrochloride

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)