| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S88746-1mg买3赠1 |
99.70% | ￥730.00 |
8 | - | - | - | - |
|
S88746-5mg促销 |
99.70% | ￥2400.00 ￥1920.00 |
6 | - | - | - | - |
|
S88746-10mg促销 |
99.70% | ￥3820.00 ￥3050.00 |
5 | - | - | - | - |
|
S88746-25mg促销 |
≥98% | ￥6220.00 ￥4970.00 |
货期：2-3天 | - | - | - | - |
|
S88746-50mg促销 |
≥98% | ￥8880.00 ￥7100.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | RG7713 (RO5028442) is a highly potent and selective Brain-Penetrant Vasopressin 1a (V1a) receptor antagonist with Kis of 1 nM (hV1a) and 39 nM (mV1a). | ||||||||||||||||||||
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| 靶点： | Ki: 1 nM (hV1a receptor), 39 nM (mV1a receptor);VasopressinReceptor | ||||||||||||||||||||
| 体外研究： | RG7713 (RO5028442) (compound 8) has excellent binding in and functional affinity for hV1a, moderate mouse affinity, and excellent selectivity versus human V2 (hV2) and human oxytocin (hOT) receptors. RG7713 (RO5028442) shows high solubility. RG7713 (RO5028442) is found to be highly selective against a panel of 89 targets. Finally, RG7713 (RO5028442) is identified as a suitable compound for clinical studies | ||||||||||||||||||||
| 参考文献： | 1. Ratni H, et al. Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment of autism via a chemogenomic and scaffold hopping approach. J Med Chem. 2015 Mar 12;58(5):2275-89. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20°C | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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