| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S88766-2mg |
≥98% | ￥400.00 |
货期：3-5天 | - | - | - | - |
|
S88766-5mg |
≥98% | ￥600.00 |
货期：3-5天 | - | - | - | - |
|
S88766-10mg |
≥98% | ￥1000.00 |
货期：3-5天 | - | - | - | - |
|
S88766-25mg |
≥98% | ￥1800.00 |
货期：3-5天 | - | - | - | - |
|
S88766-50mg |
≥98% | ￥2800.00 |
货期：3-5天 | - | - | - | - |
|
S88766-100mg |
≥98% | ￥4800.00 |
货期：3-5天 | - | - | - | - |
|
| 产品描述： | AC-264613 is a potent and selective protease-activated receptor (PAR-2) agonist with a pEC50 of 7.5 | ||||||||||||||||||||
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| 靶点： | pEC50: 7.5 (PAR-2);Protease-activatedReceptor | ||||||||||||||||||||
| 体外研究： | AC-264613 (10 μM; for 6 hours) causes a decrease of IRF5 expression and also significantly reduces p53 protein expression in macrophages. Western Blot Analysis Cell Line: Granulocyte-macrophage colony-stimulating factor (GM-CSF)-dependent macrophages Concentration: 10 μM Incubation Time: 6 hours Result: Significantly decreased IRF5 expression and reduced p53 protein levels. | ||||||||||||||||||||
| 体内研究： | AC-264613 exhibits moderate elimination half-live (T1/2=2.5±2.0 h) following i.p. administration (10 mg/kg) in male Sprague-Dawley rats | ||||||||||||||||||||
| 参考文献： | 1. Jimmi Gerner Seitzberg, et al. Discovery of potent and selective small-molecule PAR-2 agonists. J Med Chem. 2008 Sep 25;51(18):5490-3. 2. Rui Yamaguchi, et al. A protease-activated receptor 2 agonist (AC-264613) suppresses interferon regulatory factor 5 and decreases interleukin-12p40 production by lipopolysaccharide-stimulated macrophages: Role of p53. Cell Biol Int. 2016 Jun;40(6):629-41 3. Luis R Gardell, et al. Identification and characterization of novel small-molecule protease-activated receptor 2 agonists. J Pharmacol Exp Ther. 2008 Dec;327(3):799-808. | ||||||||||||||||||||
| 溶解性： | <40.03mg/ml in DMSO | ||||||||||||||||||||
| 保存条件： | -20°C | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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