货号	规格	价格	上海	北京	珠海	重庆	武汉
S88772-1mg买3赠1	98.60%	￥550.00 S88772-1mg ￥550.00 现货（买3赠1）	9 9	-	-	-	-
S88772-5mg促销	98.60%	￥1020.00 ￥816.00 S88772-5mg ￥816.00 现货	6 6	-	-	-	-
S88772-10mg促销	98.60%	￥1780.00 ￥1420.00 S88772-10mg ￥1420.00 现货	5 5	-	-	-	-
S88772-25mg促销	98.60%	￥3500.00 ￥2800.00 S88772-25mg ￥2800.00 现货	5 5	-	-	-	-

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产品描述：

RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT).

靶点：

ACAT;Acyltransferase

体内研究：

Administration of RP-64477 (0.01% and 0.03% w/w by diet) reduces significantly plasma cholesterol levels in cholesterol/cholic acid-fed rats by 29% and 61%, respectively. Food consumption is not affected by dietary incorporation of RP-64477. Animals receiving RP-64477 (10 and 30 mg/kg b.i.d.) over this period exhibit significantly lower plasma cholesterol levels on both days 4 and 7 when compare to values recorded from vehicle treated animals fed the cholesterol-containing diet. Compare to cholesterol-fed controls, after 7 days of dosing, plasma cholesterol levels are 35% and 53% lower in animals receiving 10 and 30 mg/kg b.i.d. doses of RP-64477, respectively

参考文献：

1. Bello AA, et al. RP 64477: a potent inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase with low systemic bioavailability. Biochem Pharmacol. 1996 Feb 23;51(4):413-21.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.005 ml	10.026 ml	20.051 ml
5 mM	0.401 ml	2.005 ml	4.01 ml
10 mM	0.201 ml	1.003 ml	2.005 ml
50 mM	0.04 ml	0.201 ml	0.401 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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