货号	规格	价格	上海	北京	珠海	重庆	武汉
S88788-10mg买3赠1	98.00%	￥240.00 S88788-10mg ￥240.00 现货（买3赠1）	9 9	-	-	-	-
S88788-50mg买3赠1	98.00%	￥480.00 S88788-50mg ￥480.00 现货（买3赠1）	8 8	-	-	-	-
S88788-100mg买3赠1	98.00%	￥800.00 S88788-100mg ￥800.00 现货（买3赠1）	4 4	-	-	-	-

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产品描述：

Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.

靶点：

5-HT3 Receptor:17 μM (IC50);5-HTReceptor

体内研究：

Leukocyte accumulation was dose-dependently inhibited by granisetron both at 6 and 72 h after induction of inflammation. Granisetron increased PGE(2) level at a lower dose (50 microg/pouch) but higher doses (100 and 200 microg/pouch) inhibited the release. At the same time, TNFalpha production was decreased by the lower dose and increased by higher doses of granisetron in a reciprocal fashion. The GTDS displayed non-inferiority to oral granisetron: complete control was achieved by 60% of patients in the GTDS group, and 65% in the oral granisetron group (treatment difference, -5%; 95% confidence interval, -13-3). Both treatments were well tolerated, the most common adverse event being constipation

参考文献：

1. Sanger GJ, Nelson DR. Selective and functional 5-hydroxytryptamine3 receptor antagonism by BRL 43694 (granisetron). Eur J Pharmacol. 1989 Jan 10;159(2):113-24. 2. Maleki-Dizaji N, Eteraf-Oskouei T, Fakhrjou A, The effects of 5HT3 receptor antagonist granisetron on inflammatory parameters and angiogenesis in the air-pouch model of inflammation. Int Immunopharmacol. 2010 Sep;10(9):1010-6. 3. Boccia RV, Gordan LN, Clark G, Efficacy and tolerability of transdermal granisetron for the control of chemotherapy-induced nausea and vomiting associated with moderately and highly emetogenic multi-day chemotherapy: a randomized, double-blind, phase III

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.201 ml	16.005 ml	32.009 ml
5 mM	0.64 ml	3.201 ml	6.402 ml
10 mM	0.32 ml	1.6 ml	3.201 ml
50 mM	0.064 ml	0.32 ml	0.64 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(1篇)

1. [IF=2.408] Ting-Ting Cao et al."Xanthones from Calophyllum Polyanthum Wallich ex Choisy with CYP1 enzymes inhibitory activity."CHEMISTRY & BIODIVERSITY

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