| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S88855-1mg |
≥98% | ￥1000.00 |
货期：3-5天 | - | - | - | - |
|
S88855-5mg |
≥98% | ￥3000.00 |
货期：3-5天 | - | - | - | - |
|
S88855-10mg |
≥98% | ￥5500.00 |
货期：3-5天 | - | - | - | - |
|
S88855-25mg |
≥98% | ￥9500.00 |
货期：3-5天 | - | - | - | - |
|
S88855-50mg |
≥98% | ￥18000.00 |
货期：3-5天 | - | - | - | - |
|
| 产品描述： | IACS-9571 is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1) | ||||||||||||||||||||
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| 靶点： | Epigenetic Reader Domain;EpigeneticReaderDomain | ||||||||||||||||||||
| 体外研究： | IACS-9571 is a selective dual TRIM24/BRPF1 inhibitor (Kd = 1.3/2.1 nM) with 9- and 21-fold selectivity against BRPF2 and BRPF3, respectively. IACS-9571 does not interact with the BET sub-family of bromodomains, displaying greater than 7,700-fold selectivity versus BRD4(1, 2) relative to TRIM24.IACS-9571 shows excellent cellular potency with EC50 of 50 nM.?IACS-9571 (1 μM) has potent activities against a panel of 32 bromodomains. | ||||||||||||||||||||
| 参考文献： | 1. Palmer WS, et al. Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor. J Med Chem. 2016 Feb 25;59(4):1440-54. | ||||||||||||||||||||
| 溶解性： | DMSO : 2 mg/mL, clear | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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