货号	规格	价格	上海	北京	珠海	重庆	武汉
S88860-5mg	≥98%	￥570.00 S88860-5mg ￥570.00 3-5天	0 货期：3-5天	-	-	-	-
S88860-10mg	≥98%	￥900.00 S88860-10mg ￥900.00 3-5天	0 货期：3-5天	-	-	-	-
S88860-25mg	≥98%	￥1810.00 S88860-25mg ￥1810.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

Aramchol, also known as arachidyl amido cholanoic acid, is a conjugate of arachidic acid and cholic acid. It reduces ex vivo cholesterol crystallization in native human bile and dissolves pre-formed cholesterol crystals in a dose-dependent manner.

体内研究：

Three months' administration of the fatty acid-bile acid conjugate Aramchol is significantly reduces liver fat content in patients with NAFLD. The reduction in liver fat content occurred in a dose-dependent manner and was associated with a trend of metabolic improvements, indicating that Aramchol might be used for the treatment of fatty liver disease

动物实验：

Performed a randomized, double-blind, placebo-controlled trial of 60 patients with biopsy-confirmed NAFLD (6 with nonalcoholic steatohepatitis) at 10 centers in Israel. Patients were given Aramchol (100 or 300 mg) or placebo once daily for 3 months (n = 20/group). The main end point was the difference between groups in the change in liver fat content according to magnetic resonance spectroscopy. The secondary end points focused on the differences between groups in alterations of liver enzyme levels, levels of adiponectin, homeostasis model assessment scores, and endothelial function

参考文献：

1. Eshraghian A . Current and emerging pharmacological therapy for non-alcoholic fatty liver disease[J]. World Journal of Gastroenterology, 2017, 23(42):7495-7504. 2. Safadi R , Konikoff F M , Mahamid M , et al. The Fatty Acid–Bile Acid Conjugate Aramchol Reduces Liver Fat Content in Patients With Nonalcoholic Fatty Liver Disease[J]. Clinical Gastroenterology and Hepatology, 2014, 12(12):2085-2091.e1.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.424 ml	7.121 ml	14.243 ml
5 mM	0.285 ml	1.424 ml	2.849 ml
10 mM	0.142 ml	0.712 ml	1.424 ml
50 mM	0.028 ml	0.142 ml	0.285 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

ARAMCHOL

Aramchol（C20-FABAC）

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)