| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S88863-2mg促销 |
98.40% | ￥110.00 ￥88.00 |
8 | - | - | - | - |
|
S88863-5mg促销 |
98.40% | ￥230.00 ￥184.00 |
7 | - | - | - | - |
|
S88863-10mg促销 |
98.40% | ￥400.00 ￥320.00 |
7 | - | - | - | - |
|
S88863-25mg促销 |
98.40% | ￥800.00 ￥640.00 |
3 | - | - | - | - |
|
S88863-50mg |
≥98% | ￥1360.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | Vipadenant (BIIB-014; CEB-4520) is an adenosine receptor antagonist, with Kis of 1.3 nM and 68 nM for A2A and A1, respectively | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | Ki: 1.3 nM (A2A), 68 nM (A1), 1005 nM (A3);AdenosineReceptor | ||||||||||||||||||||
| 体内研究： | Vipadenant (0.3-30 mg/kg) produces a dose-dependent reduction in catalepsy. Vipadenant (10 mg/kg) does not produce any statistically significant dyskinetic episodes in 6-OHDA-lesioned rats during a 19-day dosing regimen. In the mouse and rat haloperidol-induced hypolocomotion models, vipadenant has a minimum effective dose of 0.1 and 1 mg/kg, respectively. Vipadenant (3 and 10 mg/kg, p.o.) is able to increase contralateral rotations in 6-OHDA lesioned rats | ||||||||||||||||||||
| 参考文献： | 1. Jones N, et al. A2A receptor antagonists do not induce dyskinesias in drug-naive or L-dopa sensitized rats. Brain Res Bull. 2013 Sep;98:163-9. 2. Brian C. Shook, et al. Adenosine A2A Receptor Antagonists and Parkinson’s Disease. ACS Chem Neurosci. 2011 Oct 19; 2(10): 555-567. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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