| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S89015-5mg买3赠1 |
99.80% | ￥630.00 |
8 | - | - | - | - |
|
S89015-10mg促销 |
99.80% | ￥1020.00 ￥816.00 |
7 | - | - | - | - |
|
S89015-25mg促销 |
99.80% | ￥2040.00 ￥1630.00 |
6 | - | - | - | - |
|
S89015-100mg促销 |
99.80% | ￥4820.00 ￥3850.00 |
2 | - | - | - | - |
|
| 产品描述： | GSK-7975A is a potent and orally available CRAC channel inhibitor. | ||||||||||||||||||||
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| 靶点： | Calcium Channel;CalciumChannel | ||||||||||||||||||||
| 体内研究： | GSK-7975A inhibits local and systemic features of acute pancreatitis in TLCS-AP, CER-AP, FAEE-AP, in dose- and time-dependent manners. GSK-7975A significantly reduces increases in serum amylase, IL6, and pancreatic MPO levels; lung MPO is reduced significantly by low dose only. GSK-7975A markedly reduces pancreatic histopathology in TLCS-AP, CER-AP, and FAEE-AP | ||||||||||||||||||||
| 参考文献： | 1. Ashmole I, et al. CRACM/Orai ion channel expression and function in human lung mast cells. J Allergy Clin Immunol. 2012 Jun;129(6):1628-35.e2. 2. Rice LV, et al. Characterization of selective Calcium-Release Activated Calcium channel blockers in mast cells and T-cells from human, rat, mouse and guinea-pig preparations. Eur J Pharmacol. 2013 Mar 15;704(1-3):49-57. 3. Wen L, et al. Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models. Gastroenterology. 2015 Aug;149(2):481-92.e7. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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