| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S89018-5mg买3赠1 |
98.10% | ￥348.00 |
6 | - | - | - | - |
|
S89018-10mg买3赠1 |
98.10% | ￥500.00 |
7 | - | - | - | - |
|
S89018-25mg买3赠1 |
98.10% | ￥850.00 |
5 | - | - | - | - |
|
S89018-100mg促销 |
≥98% | ￥2460.00 ￥1960.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | OGG1-IN-08 is a potent 8-oxoguanine DNA glycosylase-1 (OGG1) inhibitor with an IC50 value of 0.22 μM. OGG1-IN-08 decreases both the glycosylase and lyase activities of OGG1 | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | IC50: 0.22 μM (OGG1) | ||||||||||||||||||||
| 体外研究： | OGG1-IN-08 (50 μM) inhibits different DNA glycosylases activities, it inhibits nei endonuclease VIII-like 1 DNA glycosylase (NEIL1)(84.56%), endonuclease III-like (NTH1)(63.09%), and Fpg (91.74%), respectively. OGG1-IN-08 (10 μM) has a inhibitory OGG1 lyase activity on a substrate containing an AP site compared with the no inhibitor control. OGG1-IN-08 (10 μM) decreases the number of bases released into solution by OGG1 for both the 8-oxo-Gua and FapyGua compared with the no inhibitor | ||||||||||||||||||||
| 参考文献： | 1. Nathan Donley,et al. Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1). ACS Chem Biol. 2015 Oct 16;10(10):2334-43. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20°C | ||||||||||||||||||||
| 配置溶液浓度参考： |
|
||||||||||||||||||||
| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
沪公网安备 31011702002021号
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京