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LIT-001

    
98.50%

(S)-2-(Dimethylcarbamothioyl)-N-(2-methyl-4-(1-methyl-1,4,5,10-tetrahydrobenzo[b]pyrazolo[3,4-e][1,4]diazepine-5-carbonyl)benzyl)pyrrolidine-1-carboxamide, Trifluoroacetate

源叶(MedMol)
S89019 一键复制产品信息
2245072-21-1
C₃₀H₃₄F₃N₇O₄S
645.70
LIT-001; LIT 001; LIT001; LIT-001 TFA; LIT-001; LIT001; LIT 001
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
S89019-5mg买3赠1
98.50%

¥280.00

5 - - - -
S89019-10mg买3赠1
98.50%

¥480.00

7 - - - -
S89019-25mg
98.50%

¥950.00

5 - - - -
S89019-100mg
≥98%

¥2750.00

货期:2-3天 - - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述: LIT-001 is the first nonpeptide oxytocin receptor (OT-R) agonist (EC50=55 nM; Ki=226 nM). LIT-001 improves social interaction in a mouse model of autism
靶点: EC50: 55 nM (OT-R) Ki: 226 nM (OT-R);OxytocinReceptor
体外研究: In vitro signaling experiments, LIT-001 is a nonbiased OT-R agonist on the two main signaling pathways of this receptor, with minor antagonist effect on V1a and agonist effect on V1b receptors, observed at high concentrations only.
体内研究: LIT-001 (10-20 mg/kg; i.p.) alleviates core symptoms in the context of autism spectrum disorders (ASD ). Animal Model: Oprm1–/– mice (bred in house on a 50% 129SVPas–50% C57BL/6J hybrid background) Dosage: 10, 20 mg/kg Administration: i.p. Result: Alleviated core symptoms in the context of ASD.
参考文献: 1. Frantz MC, et al. LIT-001, the First Nonpeptide Oxytocin Receptor Agonist that Improves Social Interaction in a Mouse Model of Autism. J Med Chem. 2018 Oct 11;61(19):8670-8692.
溶解性: Soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 1.549 ml 7.744 ml 15.487 ml
5 mM 0.31 ml 1.549 ml 3.097 ml
10 mM 0.155 ml 0.774 ml 1.549 ml
50 mM 0.031 ml 0.155 ml 0.31 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

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摩尔浓度计算器

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