货号	规格	价格	上海	北京	珠海	重庆	武汉
S89021-5mg买3赠1	99.53%	￥140.00 S89021-5mg ￥140.00 现货（买3赠1）	7 7	-	-	-	-
S89021-10mg买3赠1	99.53%	￥240.00 S89021-10mg ￥240.00 现货（买3赠1）	9 9	-	-	-	-
S89021-25mg买3赠1	99.53%	￥440.00 S89021-25mg ￥440.00 现货（买3赠1）	7 7	-	-	-	-
S89021-100mg买3赠1	99.53%	￥1140.00 S89021-100mg ￥1140.00 现货（买3赠1）	9 9	-	-	-	-

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产品描述：

Pibrentasvir (ABT-530) 是一种新型的泛基因型丙型肝炎病毒 hepatitis C virus (HCV) NS5A 抑制剂，其针对包含基因型1至6的NS5A的HCV复制子的EC50值为1.4 pM至5.0 pM

靶点：

GT5a(Cell-free assay):1.4 pM(EC50); GT1a H77(Cell-free assay):1.8 pM(EC50); GT2b(Cell-free assay):1.9 pM(EC50); GT4a(Cell-free assay):1.9 pM(EC50); GT3a(Cell-free assay):2.1 pM(EC50);GT2ab(Cell-free assay):2.3 pM;GT6a(Cell-free assay):2.8 pM;GT1b Con1(Cell-free assay):4.3 pM;GT2a JFH-1(Cell-free assay):5.0 pM;HCVProtease

细胞实验：

Cell lines: Huh-7 human hepatoma cell line, CEM-SS cells Concentrations: -- Incubation Time: 6 days Method: Antiviral activity assays for HIV-1 and HBV are performed at Southern Research Institute. Pibrentasvir is tested in an HIV-1 antiviral cytoprotection assay using CEM-SS cells and the IIIB strain of HIV-1. Briefly, virus and cells are mixed in the presence of pibrentasvir or zidovudine (AZT; positive control) and incubated for 6 days. The titers of the virus are determined beforehand such that the virus-infected control wells exhibited approximately 85% to 95% loss of cell viability due to virus replication. Therefore, antiviral effect or cytoprotection is observed when a compound prevented virus replication. Six days after infection, 20 to 25 μl of MTS reagent is added per well, and the microtiter plates are then incubated for 4 to 6 h to assess cell viability. Plates are read spectrophotometrically at 490/650 nm with a Molecular Devices Vmax or SpectraMax Plus plate reader.

参考文献：

1. Teresa I Ng, et al. Antimicrob Agents Chemother. 2017 Apr 24;61(5):e02558-16.

溶解性：

Soluble in DMSO、Ethanol

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	0.898 ml	4.492 ml	8.983 ml
5 mM	0.18 ml	0.898 ml	1.797 ml
10 mM	0.09 ml	0.449 ml	0.898 ml
50 mM	0.018 ml	0.09 ml	0.18 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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