货号	规格	价格	上海	北京	珠海	重庆	武汉
S89045-5mg	≥98%	￥380.00 S89045-5mg ￥380.00 现货	6 6	-	-	-	-
S89045-10mg	≥98%	￥550.00 S89045-10mg ￥550.00 现货	7 7	-	-	-	-
S89045-25mg	≥98%	￥1200.00 S89045-25mg ￥1200.00 现货	6 6	-	-	-	-
S89045-100mg	≥98%	￥3500.00 S89045-100mg ￥3500.00 2-3天	0 货期：2-3天	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

FOY251 是 camostat mesilate 的活性代谢产物，是 synthetic serine protease 的抑制剂。 FOY251 可抑制 SARS-CoV-2 感染

靶点：

synthetic serine protease;Serine/threoninkinase; SARS-CoV

体内研究：

FOY-251 increases the circulating levels of FGF21 of transcription and plasma are maintained with induction of liver integrated stress response (ISR) transcription target genes up to 1 wk of treatment in both ob/ob and lean mice, also increases plasma FGF21 levels when dosed to DIO mice.

细胞实验：

Cell lines: Mouse cortical collecting duct cell line (M-1 cells) Concentrations: 0.01–10 μM Incubation Time: 24 h Method: M-1 cells were cultured on semi-permeable membrane, serum deprived for 24 h, and treated with 0.01-1 μM camostat mesilate or 0.01-10 μM FOY-251 from the apical side. After 24 h incubation, transepithelial voltage (Vte) and resistance (Rte) were measured with a volt ohm meter. Ieq was determined as the ratio of Vte to Rte and was normalized by dividing Ieq by the surface area (113 mm2 ) of active membrane.

动物实验：

Animal Models: Male ob/ob mice, lean and diet-induced obese (DIO) C57BL/6 mice Dosages: 0.8 mg/g food Administration: p.o.

参考文献：

1. Ai Maekawa, et al. J Hypertens. 2009 Jan;27(1):181-9. 2. Markus Hoffmann, et al. bioRxiv. 2020 Aug 5;2020.08.05.237651. 3. Albarazanji, Kamal et al. American journal of physiology. Gastrointestinal and liver physiology vol. 316,5 (2019): G653-G667.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.443 ml	12.213 ml	24.425 ml
5 mM	0.489 ml	2.443 ml	4.885 ml
10 mM	0.244 ml	1.221 ml	2.443 ml
50 mM	0.049 ml	0.244 ml	0.489 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

FOY 251