货号	规格	价格	上海	北京	珠海	重庆	武汉
S89053-5mg	99.90%	￥380.00 S89053-5mg ￥380.00 现货	9 9	-	-	-	-
S89053-10mg	99.90%	￥550.00 S89053-10mg ￥550.00 现货	10 10	-	-	-	-
S89053-25mg	99.90%	￥1050.00 S89053-25mg ￥1050.00 现货	10 10	-	-	-	-
S89053-100mg	≥98%	￥3040.00 S89053-100mg ￥3040.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

AZD-8529 mesylate is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes

靶点：

mGluR2:285 nM (EC50);GluR

体内研究：

AZD-8529 mesylate (0.3-mg/kg, i.m.) reduces nicotine priming-induced and cue-induced reinstatement in squirrel monkeys. AZD-8529 mesylate (30 mg/kg; i.p.) decreases the increased extracellular dopamine induced by nicotine in accumbens shell of freely-moving rats. Animal Model: Sprague-Dawley rats Dosage: 10 mg/kg, 30 mg/kg Administration: Intraperitoneal injection; 2 hours before nicotine injections Result: Decreased the increased extracellular dopamine induced by nicotine (0.4 mg/kg, s.c.) in accumbens shell of freely-moving rats.

参考文献：

1. Justinova Z, et al. The Novel Metabotropic Glutamate Receptor 2 Positive Allosteric Modulator, AZD8529, Decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys. Biol Psychiatry. 2015 Oct 1;78(7):452-62.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.714 ml	8.568 ml	17.136 ml
5 mM	0.343 ml	1.714 ml	3.427 ml
10 mM	0.171 ml	0.857 ml	1.714 ml
50 mM	0.034 ml	0.171 ml	0.343 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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