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BX 430

    
99.40%

BX 430

源叶(MedMol)
S89066 一键复制产品信息
688309-70-8
C15H15Br2N3O
413.1071
BX430; BX-430; BX 430
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
S89066-5mg买3赠1
99.40%

¥340.00

8 - - - -
S89066-10mg买3赠1
99.40%

¥544.00

6 - - - -
S89066-25mg促销
99.40%

¥1080.00 ¥864.00

4 - - - -
S89066-100mg
99.40%

¥2140.00

3 - - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述: BX430 is a potent and selective noncompetitive allosteric human P2X4 receptor channels antagonist with an IC50 of 0.54 μM. BX430 has species specificity. BX430 is used for chronic pain and cardiovascular disease
靶点: IC50: 0.54 μM (human P2X4 receptor channels);P2XReceptor; CalciumChannel
体外研究: BX430 has virtually no functional impact on all other P2X subtypes, namely, P2X1-P2X3, P2X5, and P2X7, at 10-100 times its IC50[1].BX430 is a potent antagonist of zebrafish P2X4 but has no effect on rat and mouse P2X4 orthologs[1].Human P2X4-expressing cells treated with thapsigargin plus BX430 shows a significant reduction in the intracellular calcium rise evoked by ATP[1].BX430 (5 μM) markedly reduces the amplitude of ATP-evoked intracellular calcium responses in THP-1 cells。
参考文献: 1. Ase AR, et al. Identification and characterization of a selective allosteric antagonist of human P2X4 receptor channels. Mol Pharmacol. 2015 Apr;87(4):606-16. 2. Sophocleous RA, et al. Pharmacological and genetic characterisation of the canine P2X4 receptor. Br J Pharmacol. 2020 Feb 4.
溶解性: Soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.421 ml 12.103 ml 24.207 ml
5 mM 0.484 ml 2.421 ml 4.841 ml
10 mM 0.242 ml 1.21 ml 2.421 ml
50 mM 0.048 ml 0.242 ml 0.484 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

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摩尔浓度计算器

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