| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S89071-5mg买3赠1 |
99.70% | ￥400.00 |
6 | - | - | - | - |
|
S89071-10mg买3赠1 |
99.70% | ￥550.00 |
7 | 2 | - | - | - |
|
S89071-25mg买3赠1 |
99.70% | ￥1200.00 |
5 | - | - | - | - |
|
S89071-50mg买3赠1 |
99.70% | ￥2060.00 |
5 | - | - | - | - |
|
S89071-100mg买3赠1 |
99.70% | ￥3500.00 |
5 | - | - | - | - |
|
S89071-250mg |
≥98% | ￥5280.00 |
2 | - | - | - | - |
|
| 产品描述： | BAY 2416964 (compound 192) 是一种有效的、口服活性的 aryl hydrocarbon receptor (AhR) 的拮抗剂，对应的IC50值为341 nM。BAY 2416964 具有治疗实体瘤的潜力 |
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| 靶点： | AhR(Cell-free assay):341 nM;ArylHydrocarbonReceptor | ||||||||||||||||||||
| 体外研究： | BAY 2416964 (Example 192) induces AHR-regulated gene CYP1A1 expression with IC50 of 4.30 nM in a human monocytic U937 cells. | ||||||||||||||||||||
| 体内研究： | In vivo assays: BAY 2416964 (Example 192) is dissolved in Ethanol/Solutol/Water (10/40/50) and given at 30 mg/kg, QD, p.o.. The efficacy is calculated based on tumor volume. BAY 2416964 (Example 192) is shown to have the potential for solid tumour treatment. | ||||||||||||||||||||
| 细胞实验： | Cell lines: human monocytic U937 cell line Concentrations: 3.1 nmol/L, 11 nmol/L, 38 nmol/L, 130 nmol/L, 470 nmol/L, 1.6 pmol/L, 5.7 pmol/L and 20 pmol/L Incubation Time: 20 h Method: Cells in medium (tryptophan free RPMI, 1% FCS, 2mM Glutamine) supplemented with 150 μM kynurenic acid are grown for 20 hours in absence (negative control) or presence of increasing concentrations of BAY 2416964 (typical dilutions: 72 pmol/L, 0.25 nmol/L, 0.89 nmol/L; 3.1 nmol/L, 11 nmol/L, 38 nmol/L, 130 nmol/L, 470 nmol/L, 1.6 pmol/L, 5.7 pmol/L and 20 pmol/L in duplicates). | ||||||||||||||||||||
| 动物实验： | Animal Models: Female C57/BL6N mice with B16F10OVA tumor cells Dosages: 30 mg/kg Administration: Oral gavage | ||||||||||||||||||||
| 参考文献： | 1. Gutcher Ilona, et al. 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamides for the treatment of cancer. WO2018146010A1 | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、Ethanol | ||||||||||||||||||||
| 保存条件： | -20°C | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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营业执照(三证合一)
北京