货号	规格	价格	上海	北京	武汉	南京
S89084-1mg	≥98%	￥120.00 S89084-1mg ￥120.00 现货	10 10	-	-	-
S89084-5mg	≥98%	￥390.00 S89084-5mg ￥390.00 现货	10 10	-	-	-
S89084-10mg	≥98%	￥540.00 S89084-10mg ￥540.00 现货	8 8	-	-	-
S89084-25mg	≥98%	￥1000.00 S89084-25mg ￥1000.00 现货	4 4	-	-	-
S89084-50mg	≥98%	￥1660.00 S89084-50mg ￥1660.00 现货	2 2	-	-	-
S89084-100mg	≥98%	￥2780.00 S89084-100mg ￥2780.00 现货	2 2	-	-	-

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产品介绍

BMS-986260, an immuno-oncology agent, is a potent, selective, and orally active TGFβR1 inhibitor (IC50=1.6 nM). BMS-986260 displays exquisite selectivity for TGFβR1 over its isozyme TGFβR2, as well as in a panel of more than 200 kinases examined. BMS-986260 inhibits TGFβ mediated nuclear translocation of pSMAD2/3 in MINK and NHLF cells lines with an IC50 of 350 nM and 190 nM, respectively

产品描述：

靶点：

TGF-β Receptor;TGF-beta/Smad

体外研究：

BMS-986260 is a highly potent TGFβR1 inhibitor in both human (Kiapp=0.8 nM) and mouse (Kiapp= 1.4 nM) biochemical assays. BMS-986260 also inhibits TGFβ induced SMAD phosphorylation in NIH3T3 cell line, primary human T cells, and mouse and human whole blood. BMS-986260 inhibits TGF-β mediated induction of regulatory T cell (Treg) by downregulation of FOXP3 expression and a repression of CD25 with an IC50 of 230 nM

参考文献：

1. Velaparthi U, et al. Discovery of BMS-986260, a Potent, Selective, and Orally Bioavailable TGFβR1 Inhibitor as an Immuno-oncology Agent. ACS Med Chem Lett. 2020;11(2):172-178. Published 2020 Jan 28.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.612 ml	13.062 ml	26.124 ml
5 mM	0.522 ml	2.612 ml	5.225 ml
10 mM	0.261 ml	1.306 ml	2.612 ml
50 mM	0.052 ml	0.261 ml	0.522 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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