| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S89084-1mg促销 |
≥98% | ￥120.00 ￥108.00 |
10 | - | - | - | - |
|
S89084-5mg促销 |
≥98% | ￥390.00 ￥350.00 |
10 | - | - | - | - |
|
S89084-10mg促销 |
≥98% | ￥540.00 ￥486.00 |
8 | - | - | - | - |
|
S89084-25mg促销 |
≥98% | ￥1000.00 ￥900.00 |
4 | - | - | - | - |
|
S89084-50mg促销 |
≥98% | ￥1660.00 ￥1490.00 |
2 | - | - | - | - |
|
S89084-100mg促销 |
≥98% | ￥2780.00 ￥2500.00 |
2 | - | - | - | - |
|
| 产品描述： | BMS-986260, an immuno-oncology agent, is a potent, selective, and orally active TGFβR1 inhibitor (IC50=1.6 nM). BMS-986260 displays exquisite selectivity for TGFβR1 over its isozyme TGFβR2, as well as in a panel of more than 200 kinases examined. BMS-986260 inhibits TGFβ mediated nuclear translocation of pSMAD2/3 in MINK and NHLF cells lines with an IC50 of 350 nM and 190 nM, respectively | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | TGF-β Receptor;TGF-beta/Smad | ||||||||||||||||||||
| 体外研究： | BMS-986260 is a highly potent TGFβR1 inhibitor in both human (Kiapp=0.8 nM) and mouse (Kiapp= 1.4 nM) biochemical assays. BMS-986260 also inhibits TGFβ induced SMAD phosphorylation in NIH3T3 cell line, primary human T cells, and mouse and human whole blood. BMS-986260 inhibits TGF-β mediated induction of regulatory T cell (Treg) by downregulation of FOXP3 expression and a repression of CD25 with an IC50 of 230 nM | ||||||||||||||||||||
| 参考文献： | 1. Velaparthi U, et al. Discovery of BMS-986260, a Potent, Selective, and Orally Bioavailable TGFβR1 Inhibitor as an Immuno-oncology Agent. ACS Med Chem Lett. 2020;11(2):172-178. Published 2020 Jan 28. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
|
||||||||||||||||||||
| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
沪公网安备 31011702002021号
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
