| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S89098-1mg |
≥98% | ￥250.00 |
货期：2-4周 | - | - | - | - |
|
S89098-2mg |
≥98% | ￥400.00 |
货期：2-4周 | - | - | - | - |
|
S89098-10mg |
≥98% | ￥589.00 |
货期：2-3天 | - | - | - | - |
|
S89098-5mg |
≥98% | ￥700.00 |
货期：2-4周 | - | - | - | - |
|
S89098-25mg |
≥98% | ￥2300.00 |
货期：2-3天 | - | - | - | - |
|
S89098-50mg |
≥98% | ￥3500.00 |
货期：2-4周 | - | - | - | - |
|
| 产品描述： | GR 125743 is a selective 5-HT1B/1D receptor antagonist, with pKis of 8.85 and 8.31 for wild-type h5-HT1B and wild-type h5-HT1D, respectively. GR 125743 is used for the research of Parkinson's disease and cardiovascular diseases | ||||||||||||||||||||
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| 靶点： | human 5-HT1B Receptor:8.85 (pKi);human 5-HT1D Receptor:8.31 (pKi);5-HTReceptor | ||||||||||||||||||||
| 体外研究： | GR 125743 has a Kd of 0.61 nM for h5-HT1B | ||||||||||||||||||||
| 体内研究： | GR 125743 (0.3 mg/kg; i.p.) produces significant decreases in extracellular 5-HT in the frontal cortex of the conscious guinea pig. Animal Model: Male Dunkin Hartley guinea-pigs (350-450 g) Dosage: 0.3 mg/kg Administration: Intraperitoneal injection Result: Produced significant transient increases in extracellular 5-HT. | ||||||||||||||||||||
| 参考文献： | 1. T Wurch, et al. Induction of a high-affinity ketanserin binding site at the 5-Hydroxytryptamine(1B) receptor by modification of its carboxy-terminal intracellular portion. Characterization of human serotonin 1D and 1B receptors using [3H]-GR-125743, a nov 2. Roberts, C., et al. The role of 5-HT1B/1D receptors in the modulation of 5-hydroxytryptamine levels in the frontal cortex of the conscious guinea pig. European Journal of Pharmacology. 1997 May 12;326(1):23-30. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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