| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S89114-5mg买3赠1 |
99.60% | ￥700.00 |
6 | - | - | - | - |
|
S89114-10mg促销 |
99.60% | ￥1020.00 ￥816.00 |
6 | - | - | - | - |
|
S89114-25mg促销 |
99.60% | ￥1950.00 ￥1560.00 |
5 | - | - | - | - |
|
S89114-50mg促销 |
99.60% | ￥3060.00 ￥2440.00 |
2 | - | - | - | - |
|
S89114-100mg促销 |
≥98% | ￥5100.00 ￥4080.00 |
货期：2-3天 | - | - | - | - |
|
S89114-200mg促销 |
≥98% | ￥7650.00 ￥6120.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | VAF347 is a cell permeable and highly affinity aryl hydrocarbon receptor (AhR) agonist and induces AhR signaling. VAF347 inhibits the development of CD14+CD11b+ monocytes from granulo-monocytic (GM stage) precursors. VAF347 has anti-inflammatory effects | ||||||||||||||||||||
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| 靶点： | Aryl hydrocarbon receptor;ArylHydrocarbonReceptor | ||||||||||||||||||||
| 体外研究： | VAF347 (0.01-20 μM; 48-72 hours; HL-60 cells) treatment enhances retinoic acid-induced cell cycle arrest. VAF347 (20 μM; 48 hours; HL-60 cells) treatment augments retinoic acid-induced expression of AhR, Lyn, Vav1, and c-Cbl as well as p47phox. Several interactions of partners in the signalsome appear to be enhanced: Fgr interaction with c-Cbl, CD38, and with pS259c-Raf and AhR interaction with c-Cbl and Lyn. VAF347 inhibits IL-4+ GM-CSF induced IL-6 production in MM1 cells with an IC50 of ~5 nM. Cell Cycle Analysis Cell Line: HL-60 cells Concentration: 10 nM, 100 nM, 1 μM, 10 μM, 20 μM Incubation Time: 48 hours or 72 hours Result: Enhanced retinoic acid-induced cell cycle arrest in G1/0. Western Blot Analysis Cell Line: HL-60 cells Concentration: 20 μM Incubation Time: 48 hours Result: Augmented retinoic acid-induced expression of AhR, Lyn, Vav1, and c-Cbl as well as p47phox. | ||||||||||||||||||||
| 体内研究： | In wild-type mice, VAF347 treatment leads to a strong reduction of total serum IgE levels compared with vehicle-treated animals. IL-5 levels in the bronchoalveolar fluid are inhibited to a comparable degree. AhR-deficient mice are resistant to the VAF347's ability to block allergic lung inflammation in vivo。 | ||||||||||||||||||||
| 参考文献： | 1. Ibabao CN, et al. The AhR agonist VAF347 augments retinoic acid-induced differentiation in leukemia cells. FEBS Open Bio. 2015 Apr 8;5:308-18. 2. B Paige Lawrence, et al. Activation of the aryl hydrocarbon receptor is essential for mediating the anti-inflammatory effects of a novel low-molecular-weight compound. Blood. 2008 Aug 15;112(4):1158-65. |
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| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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营业执照(三证合一)
北京