| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S89121-1mg促销 |
≥98% | ￥300.00 ￥230.00 |
10 | - | - | - | - |
|
S89121-5mg促销 |
≥98% | ￥700.00 ￥550.00 |
10 | - | - | - | - |
|
S89121-10mg促销 |
≥98% | ￥1300.00 ￥1030.00 |
7 | - | - | - | - |
|
S89121-25mg促销 |
≥98% | ￥2600.00 ￥2070.00 |
3 | - | - | - | - |
|
S89121-50mg促销 |
≥98% | ￥4300.00 ￥3430.00 |
2 | - | - | - | - |
|
| 产品描述： | NCGC00092410 is a potent, selective, and nonsugar glucocerebrosidase (GC) inhibitor, with an IC50 of 31 nM. NCGC00092410 shows no activity against the related hydrolases at concentrations up to 77 μM. NCGC00092410, a GC chaperone, and increases the activity and lysosomal localization of glucocerebrosidase in mutant cell lines. NCGC00092410 can be used for the research of Gaucher disease | ||||||||||||||||||||
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| 靶点： | IC50: 31 nM (glucocerebrosidase) | ||||||||||||||||||||
| 体外研究： | NCGC00092410 (7.3-130 nM; 25 min) inhibits the GC activity at various substrate concentrations (10-150 μM) in a dose-dependent manner. NCGC00092410 (55-40 μM; 2 d) increases the GC activity in the N370S mutant fibroblasts. NCGC00092410 (40 μM; 60-72 h) increases the lysosomal localization of GC in gaucher fibroblasts | ||||||||||||||||||||
| 参考文献： | 1. Zheng W, et, al. Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease. Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13192-7. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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