货号	规格	价格	上海	北京	珠海	重庆	武汉
S89122-5mg买3赠1	99.90%	￥640.00 S89122-5mg ￥640.00 现货（买3赠1）	2 2	-	-	-	-
S89122-10mg买3赠1	99.90%	￥1040.00 S89122-10mg ￥1040.00 现货（买3赠1）	3 3	-	-	-	-
S89122-25mg买3赠1	99.90%	￥2080.00 S89122-25mg ￥2080.00 现货（买3赠1）	5 5	-	-	-	-
S89122-100mg	99.90%	￥6000.00 S89122-100mg ￥6000.00 现货	3 3	-	-	-	-

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产品描述：

BAMB-4 (ITPKA-IN-C14) is a specific and membrane-permeable ITPKA inhibitor. BAMB-4 has high stability and membrane permeability and against the inositol-1,4,5-trisphosphate (InsP3) kinase activity of inositol-1,4,5-trisphosphate-3-kinase A (ITPKA) with an IC50 value of 20 μM. BAMB-4 can be used for the research of metastasis of lung cancer

靶点：

IC50: 37 μM (ITPKA); 20 μM (InsP3 kinase)

体外研究：

BAMB-4 (0.3-40 μM) has ITPKA inhibiton effect with an IC50 value of 37 μM. BAMB-4 (40 μM) inhibits InsP3 kinase activity with an IC50 value of 20 μM. BAMB-4 (100 μM, overnight) has high specificity and the high cellular uptake. BAMP-4 (0, 10, 20 and 40 μM) shows increased Km and decreased Vmax. BAMP-4 (0-30 μM) is a mixed type inhibitor with respect to ATP and InsP3 and does not only affect binding of ATP but also binding of InsP3，which affects turnover of two substrate exhibit a higher inhibition specifcity

参考文献：

1. Dominik Schröder, et al. Identification of a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A. Biochem Biophys Res Commun. 2013 Sep 20;439(2):228-34.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.964 ml	19.82 ml	39.64 ml
5 mM	0.793 ml	3.964 ml	7.928 ml
10 mM	0.396 ml	1.982 ml	3.964 ml
50 mM	0.079 ml	0.396 ml	0.793 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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