| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S89138-5mg买3赠1 |
99.10% | ￥720.00 |
5 | - | - | - | - |
|
S89138-10mg促销 |
99.10% | ￥1230.00 ￥984.00 |
6 | - | - | - | - |
|
S89138-25mg促销 |
99.10% | ￥2550.00 ￥2040.00 |
5 | - | - | - | - |
|
S89138-100mg促销 |
≥98% | ￥6400.00 ￥5120.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | Azumolene (EU4093 free base), a Dantrolene analog, is a muscle relaxant. Azumolene is a ryanodine receptor (RyR) modulator and inhibits the calcium-release through ryanodine receptor. Azumolene can be used for malignant hyperthermia research | ||||||||||||||||||||
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| 靶点： | Calcium Channel;CalciumChannel | ||||||||||||||||||||
| 体外研究： | Pretreatment with 20 µM Azumolene for 1-2 min inhibits SOCE activated by subsequent addition of caffeine and ryanodine to promote RyR-dependent sarcoplasmic reticulum Ca2+ store depletion in mouse myotubes and adult muscle fibers。 | ||||||||||||||||||||
| 体内研究： | The effect of Azumolene (EU4093) on the twitch of the intact rat soleus preparation is nearly maximal at a dose of 20 mg/kg. This dose of Azumolene reduces the amplitude of the twitch to 31.9% of the control value. The contraction of intrafusal muscle as measured by the response of spindle afferent discharge is also reduced by Azumolene。 | ||||||||||||||||||||
| 参考文献： | 1. G C Leslie, et al. The effect of EU4093 (azumolene sodium) on the contraction of intrafusal muscle in the soleus muscle of the anaesthetized rat. Br J Pharmacol. 1989 Aug;97(4):1151-6. 2. Viktor Yarotskyy, et al. Accelerated activation of SOCE current in myotubes from two mouse models of anesthetic- and heat-induced sudden death. PLoS One. 2013 Oct 15;8(10):e77633. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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