货号	规格	价格	上海	北京	珠海	重庆	武汉
S89155-5mg	≥98%	￥390.00 S89155-5mg ￥390.00 3-5天	0 货期：3-5天	-	-	-	-
S89155-10mg	≥98%	￥590.00 S89155-10mg ￥590.00 3-5天	0 货期：3-5天	-	-	-	-
S89155-25mg	≥98%	￥1150.00 S89155-25mg ￥1150.00 3-5天	0 货期：3-5天	-	-	-	-
S89155-100mg	≥98%	￥3060.00 S89155-100mg ￥3060.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

Fosravuconazole L-lysine ethanolate (BMS-379224 L-lysine ethanolate), a proagent of Ravuconazole, is an orally active broad spectrum antifungal agent. Fosravuconazole L-lysine ethanolate can be used for candidiasis, onychomycosis and parasitemia research

靶点：

Fungal; Parasite;Parasite; Antifungal

体外研究：

Fosravuconazole has potent in vitro antifungal activity against a wide range of fungal species, including Candida, Aspergillus, and Trichophyton species

体内研究：

Fosravuconazole (E-1224; 10-50 mg/kg; oral administration; daily; for 20 days) treatment suppresses the parasitemia and prevents death in mice infected with the T. cruzi Y strain. Animal Model: Swiss female mice (20-24 g) inoculated with trypomastigotes (Y strain). Dosage: 10 mg/kg, 20 mg/kg, 30 mg/kg, 40 mg/kg, 50 mg/kg Administration: Oral administration; daily; for 20 days Result: Suppressed the parasitemia and prevented death.

参考文献：

1. Shinichi Watanabe, et al. Efficacy and safety of fosravuconazole L-lysine ethanolate, a novel oral triazole antifungal agent, for the treatment of onychomycosis: A multicenter, double-blind, randomized phase III study. J Dermatol. 2018 Oct;45(10):1151-1159. 2. Katsura Hata, et al. Development of E1224 by leveraging a strategic partnership for the medicines creation against neglected tropical diseases. Parasitol Int. 2020 Dec 25;81:102278. 3. Lívia de Figueiredo Diniz, et al. Outcome of E1224-Benznidazole Combination Treatment for Infection with a Multidrug-Resistant Trypanosoma cruzi Strain in Mice. Antimicrob Agents Chemother. 2018 May 25;62(6):e00401-18.

溶解性：

Soluble in DMSO、H2O

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.352 ml	6.759 ml	13.518 ml
5 mM	0.27 ml	1.352 ml	2.704 ml
10 mM	0.135 ml	0.676 ml	1.352 ml
50 mM	0.027 ml	0.135 ml	0.27 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

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Fosravuconazole L-lysine ethanolate

L-lysine compound with (((2S,3R)-3-(4-(4-cyanophenyl)thiazol-2-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-yl)oxy)methyl dihydrogen phosphate and ethanol (1:1:1)

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)