货号	规格	价格	上海	北京	珠海	重庆	武汉
S89158-5mg买3赠1	99.90%	￥578.00 S89158-5mg ￥578.00 现货（买3赠1）	5 5	-	-	-	-
S89158-10mg买3赠1	99.90%	￥740.00 S89158-10mg ￥740.00 现货（买3赠1）	7 7	-	-	-	-
S89158-25mg买3赠1	99.90%	￥1150.00 S89158-25mg ￥1150.00 现货（买3赠1）	6 6	-	-	-	-
S89158-100mg买3赠1	≥98%	￥3400.00 S89158-100mg ￥3400.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-

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产品描述：

AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.

靶点：

ATM:6.2 nM (IC50);ATM:0.31 μM (IC50, in cell);ATM/ATR

体外研究：

AZ32 is a next-generation blood-brain barrier (BBB)-penetrating ATM inhibitor. AZ32 blocks the DNA damage response and radiosensitized GBM cells in vitro.

体内研究：

AZ32, with enhanced BBB penetration, is highly efficient in vivo as radiosensitizer in syngeneic and human, orthotopic mouse glioma model compared with AZ31. AZ32 is a specific inhibitor of the ATM kinase that possesses good BBB penetration in mouse. Following a single oral dose of AZ32 (200 mg/kg) in mice, the free-brain concentrations of AZ32 are in excess of the cellular IC50 for approximately 22 hours.

参考文献：

1. Karlin J, et al. Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice. Mol Cancer Ther. 2018 Aug;17(8):1637-1647.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.045 ml	15.227 ml	30.453 ml
5 mM	0.609 ml	3.045 ml	6.091 ml
10 mM	0.305 ml	1.523 ml	3.045 ml
50 mM	0.061 ml	0.305 ml	0.609 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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