| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S89161-5mg促销 |
≥98% | ￥180.00 ￥162.00 |
10 | - | - | - | - |
|
S89161-10mg促销 |
≥98% | ￥290.00 ￥260.00 |
3 | - | - | - | - |
|
S89161-25mg促销 |
≥98% | ￥570.00 ￥512.00 |
6 | - | - | - | - |
|
S89161-50mg促销 |
≥98% | ￥970.00 ￥872.00 |
3 | - | - | - | - |
|
S89161-100mg促销 |
≥98% | ￥1700.00 ￥1530.00 |
2 | - | - | - | - |
|
| 产品描述： | Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity. | ||||||||||||||||||||
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| 靶点： | Epoxide Hydrolase;FLAP;FLAP; EpoxideHydrolase | ||||||||||||||||||||
| 体内研究： | Diflapolin (1-10 mg/kg; i.p.; 30min before zymosan injection) exhibits potent anti-inflammatory properties in in-vivo experiments | ||||||||||||||||||||
| 动物实验： | 1: Vieider L, Romp E, Temml V, Fischer J, Kretzer C, Schoenthaler M, Taha A, Hernández-Olmos V, Sturm S, Schuster D, Werz O, Garscha U, Matuszczak B. Synthesis, Biological Evaluation and Structure-Activity Relationships of Diflapolin Analogues as Dual sEH/FLAP Inhibitors. ACS Med Chem Lett. 2018 Nov 29;10(1):62-66. doi: 10.1021/acsmedchemlett.8b00415. PMID: 30655948; PMCID: PMC6331193. 2: Garscha U, Romp E, Pace S, Rossi A, Temml V, Schuster D, König S, Gerstmeier J, Liening S, Werner M, Atze H, Wittmann S, Weinigel C, Rummler S, Scriba GK, Sautebin L, Werz O. Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase. Sci Rep. 2017 Aug 24;7(1):9398. doi: 10.1038/s41598-017-09795-w. PMID: 28839250; PMCID: PMC5571211. | ||||||||||||||||||||
| 参考文献： | 1. Garscha U, Romp E, Pace S, et al. Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase. Sci Rep. 2017;7(1):9398. Published 2017 Aug 24. doi:10.1038/s41598-017-09795-w | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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营业执照(三证合一)
北京