货号	规格	价格	上海	北京	珠海	重庆	武汉
S89182-5mg促销	98.00%	￥255.00 ￥204.00 S89182-5mg ￥204.00 现货	6 6	-	-	-	-
S89182-10mg促销	98.00%	￥408.00 ￥326.00 S89182-10mg ￥326.00 现货	6 6	-	-	-	-
S89182-25mg促销	98.00%	￥714.00 ￥570.00 S89182-25mg ￥570.00 现货	5 5	-	-	-	-
S89182-100mg	≥98%	￥1630.00 S89182-100mg ￥1630.00 2-3天	0 货期：2-3天	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

ML-193 (CID 1261822) is a potent and selective antagonist of GPR55, with an IC50 of 221 nM. ML-193 shows more than 27-fold selectivity for GPR55 over GPR35, CB1 and CB2. ML-193 can improve the motor and the sensorimotor deficits of Parkinson’s disease (PD) rats

靶点：

IC50: 221 nM (GPR55);CannabinoidReceptor

体外研究：

ML-193 (0.01-100 μM; pretreated for 15 min) inhibits β-arrestin trafficking induced by L-α-lysophophosphatidylinositol (LPI, 10 μM) and ML186 (1 μM) with IC50s of 0.22 μM and 0.12 μM, respectively. ML-193 (0.01-10 μM; pretreated for 30 min) decreases the LPI-mediated ERK1/2 phosphorylation, with an IC50 of 0.2 μM in U2OS cells. ML-193 (5 μM; pretreated for 30 min) attenuates the GPR55 agonists induced increases in hNSCs proliferation rates. ML-193 (5 μM; 10 d) attenuates the ML184-induced increases in hNSCs differentiation

体内研究：

ML193 (1 and 5 µg/rat; intra-striatal at a rate of 1 μL/min) attenuates sensorimotor deficits and slip steps, increases motor coordination in PD rats. Animal Model: Male Wistar rats (200-250 g) were induced experimental Parkinson by 6-hydroxydopamine (6-OHDA, 10 µg/rat) Dosage: 1 and 5 µg/rat Administration: Injected into the right striatum at a rate of 1 μL/min Result: Increased the time on the rotarod, decreased latency to remove the label and slip steps in 6-OHDA-lesioned rats.

参考文献：

1. Heynen-Genel S, et, al. Screening for Selective Ligands for GPR55-Antagonists. Probe Reports from the NIH Molecular Libraries Program. 2010 Oct 30. 2. Kotsikorou E, et, al. Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry. 2013 Dec 31;52(52):9456-69. 3. Fatemi I, et, al. The effect of intra-striatal administration of GPR55 agonist (LPI) and antagonist (ML193) on sensorimotor and motor functions in a Parkinson's disease rat model. Acta Neuropsychiatr. 2021 Feb;33(1):15-21. 4. Hill JD, et, al. Activation of GPR55 increases neural stem cell proliferation and promotes early adult hippocampal neurogenesis. Br J Pharmacol. 2018 Aug;175(16):3407-3421.

溶解性：

可溶于DMSO

保存条件：

2-8℃,避光

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.895 ml	9.477 ml	18.954 ml
5 mM	0.379 ml	1.895 ml	3.791 ml
10 mM	0.19 ml	0.948 ml	1.895 ml
50 mM	0.038 ml	0.19 ml	0.379 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置