货号	规格	价格	上海	北京	珠海	重庆	武汉
S89194-5mg促销	99.74%	￥132.00 ￥105.00 S89194-5mg ￥105.00 现货	4 4	-	-	-	-
S89194-10mg促销	99.74%	￥204.00 ￥182.00 S89194-10mg ￥182.00 现货	7 7	-	-	-	-
S89194-25mg买3赠1	99.74%	￥410.00 S89194-25mg ￥410.00 现货（买3赠1）	8 8	-	-	-	-
S89194-100mg买3赠1	99.74%	￥1150.00 S89194-100mg ￥1150.00 现货（买3赠1）	3 3	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

MCU-i4 是 mitochondrial calcium uniporter (MCU) 复合物的负调节剂，可直接结合 MICU1 中的特定裂缝并减少线粒体 Ca2+ 流入

靶点：

MCU1;MitochondrialMetabolism

体外研究：

MCU-i4 decreases mitochondrial Ca2+ influx. Docking simulations reveal that MCU-i4 directly binds a specific cleft in MICU1, a key element of the MCU complex that controls channel gating. Accordingly, in MICU1-silenced or deleted cells, the inhibitory effect of MCU-i4 is lost. Moreover, MCU-i4 fails to inhibit mitochondrial Ca2+ uptake in cells expressing a MICU1 mutated in the critical amino acids that forge the predicted binding cleft.

细胞实验：

Cell lines: C2C12 myoblasts Concentrations: 10 μM Incubation Time: 24 h Method: Growing medium of 90% confluent C2C12 myoblasts is replaced with DMEM containing 2%-heat inactivated horse serum (HS) (differentiation medium). Five days later, cells are incubated for 24 h with MCU-i4 (10 μM) or with DMSO alone (0.1% v/v). At the end of the experiment, myotubes images are taken and myotubes width is measured by means of ImageJ software.

参考文献：

1. Giulia Di Marco, et al. A High-Throughput Screening Identifies MICU1 Targeting Compounds. Cell Rep. 2020 Feb 18;30(7):2321-2331.e6.

溶解性：

Soluble in DMSO、Ethanol

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.651 ml	13.255 ml	26.51 ml
5 mM	0.53 ml	2.651 ml	5.302 ml
10 mM	0.265 ml	1.326 ml	2.651 ml
50 mM	0.053 ml	0.265 ml	0.53 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置