货号	规格	价格	上海	北京	珠海	重庆	武汉
S89199-5mg买3赠1	98.20%	￥1000.00 S89199-5mg ￥1000.00 现货（买3赠1）	3 3	-	-	-	-
S89199-10mg买3赠1	98.20%	￥1500.00 S89199-10mg ￥1500.00 现货（买3赠1）	4 4	-	-	-	-
S89199-25mg买3赠1	98.20%	￥2800.00 S89199-25mg ￥2800.00 现货（买3赠1）	5 5	-	-	-	-
S89199-100mg	≥98%	￥6150.00 S89199-100mg ￥6150.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

BIBO3304 TFA is a potent, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist, with subnanomolar affinity for both the human and the rat Y1 receptor (IC50=0.38 and 0.72 nM, respectively)

靶点：

Neuropeptide Y Receptor;NeuropeptideYReceptor

体外研究：

BIBO3304 TFA (30 μg; bilateral paraventricular nucleus injection) attenuates the hyperphagia following fasting. BIBO3304 TFA (15-60 μg) dose-dependently inhibits the feeding reponse mediated by 1 μg NPY. BIBO3304 TFA (0.5 μM; p.o.) significantly increases serum insulin levels. Animal Model: Adult male Chbb:Thom rats weighing between 300 and 340g Dosage: 30 μg Administration: bilateral paraventricular nucleus injection Result: Attenuated the hyperphagia following fasting, especially during the first 2 h of refeeding. Animal Model: 7-week-old C57BL/6JAusb mice Dosage: 0.5 μM Administration: p.o. Result: Significantly increased serum insulin levels.

参考文献：

1. Wieland HA, et al. Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents. Br J Pharmacol. 1998 Oct;125(3):549-55. 2. Loh K, et al. Inhibition of Y1 receptor signaling improves islet transplant outcome. Nat Commun. 2017 Sep 8;8(1):490.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.554 ml	7.768 ml	15.536 ml
5 mM	0.311 ml	1.554 ml	3.107 ml
10 mM	0.155 ml	0.777 ml	1.554 ml
50 mM	0.031 ml	0.155 ml	0.311 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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