货号	规格	价格	上海	北京	珠海	重庆	武汉
S89223-5mg买3赠1	98.10%	￥650.00 S89223-5mg ￥650.00 现货（买3赠1）	6 6	-	-	-	-
S89223-10mg买3赠1	98.10%	￥1000.00 S89223-10mg ￥1000.00 现货（买3赠1）	5 5	-	-	-	-
S89223-25mg买3赠1	98.10%	￥2000.00 S89223-25mg ￥2000.00 现货（买3赠1）	6 6	-	-	-	-
S89223-100mg	≥98%	￥6200.00 S89223-100mg ￥6200.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

ZYN57939 is RNA polymerase I inhibitor for treating RNA polymerase I- mediated diseases. ZYN57939 showed inhibitory activity with IC50 of 0.855 μM against human HT- 29 cancer cell lines.

靶点：

DNA/RNA Synthesis;DNA/RNASynthesis

体内研究：

MTR-106 oral and i.v. administration significantly impaired tumor growth in BRCA-deficient xenograft mouse models.?However, MTR-106 showed modest activity against talazoparib-resistant xenograft models.In rats, the drug rapidly distributes to tissues within 5 min, and its average concentrations were 12-fold higher in the tissues than in the plasma.Overall, MTR-106 as a novel G-quadruplex stabilizer with high tissue distribution, and it may serve as a potential anticancer agent.

参考文献：

1. Discovery of MTR-106 as a highly potent G-quadruplex stabilizer for treating BRCA-deficient cancers[J]. Investigational New Drugs, 2021:1-9.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.903 ml	9.513 ml	19.025 ml
5 mM	0.381 ml	1.903 ml	3.805 ml
10 mM	0.19 ml	0.951 ml	1.903 ml
50 mM	0.038 ml	0.19 ml	0.381 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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浓度

体积

分子摩尔量

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MTR-106

5H-Benzothiazolo[3,2-a][1,8]naphthyridine-6-carboxamide, 2-[(3aR,6aS)-hexahydro-5-methylpyrrolo[3,4-c]pyrrol-2(1H)-yl]-N-[(5-methyl-2-pyrazinyl)methyl]-5-oxo-, rel-

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)